Contrave and Lantus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Lantus (insulin glargine recombinant). Common drug interactions include constipation among females and application site discolouration among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Lantus. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

On Jul, 20, 2026

37 people who take Contrave and Lantus together, and have interactions are studied.

What are the common drug interactions of Contrave and Lantus, by gender? *:

female:

Constipation
Diarrhoea
Anxiety
Blood glucose increased
Fatigue (feeling of tiredness)
Feeling jittery
Food craving
Headache (pain in head)
Heart rate increased
Nervousness

male:

Application site discolouration
Application site pain
Wound secretion
Erection increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Painful erection
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neck pain

What are the common drug interactions of Contrave and Lantus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Anxiety
Blood glucose increased
Constipation
Diarrhoea
Fatigue (feeling of tiredness)
Feeling jittery
Food craving
Headache (pain in head)
Heart rate increased
Nervousness

50-59:

Disturbance in attention
Tinnitus (a ringing in the ears)
Anaphylactic reaction (serious allergic reaction)
Constipation
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Hot flush (sudden feelings of heat)
Insomnia (sleeplessness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

60+:

Application site discolouration
Application site pain
Constipation
Diarrhoea
Glycosylated haemoglobin increased
Renal disorder (kidney disease)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Stress
Anxiety
Arthralgia (joint pain)

What are the existing conditions these people have? *

High Blood Cholesterol: 18 people, 48.65%
Stress And Anxiety: 15 people, 40.54%
Thyroid Diseases: 11 people, 29.73%
Affective Disorder (mental disorder): 10 people, 27.03%
High Blood Pressure: 10 people, 27.03%
Constipation: 10 people, 27.03%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 27.03%
Depression: 6 people, 16.22%
Gastric Ulcer (stomach ulcer): 5 people, 13.51%
Pain: 5 people, 13.51%

* Approximation only. Some reports may have incomplete information.

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