Copaxone and Cytoxan drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Copaxone (glatiramer acetate) and Cytoxan (cyclophosphamide). Common drug interactions include blood sodium decreased among females and mobility decreased among males.
The phase IV clinical study analyzes what interactions people have when they take Copaxone and Cytoxan. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.
What is Copaxone?
Copaxone has active ingredients of glatiramer acetate. It is often used in multiple sclerosis. eHealthMe is studying from 56,931 Copaxone users. Check the latest studies of Copaxone.
What is Cytoxan?
Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.
28 people who take Copaxone and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Copaxone and Cytoxan, by gender? *:
female:
- Blood sodium decreased
- Bloody discharge
- Bone disorder
- Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
- Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
- Breast cancer metastatic
- Breast cancer recurrent
- Breast swelling
- Breathing-related sleep disorder
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
male:
- Mobility decreased (ability to move is reduced)
- Muscular weakness (muscle weakness)
- Pain in extremity
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Bone pain
- Coma (state of unconsciousness lasting more than six hours)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Depression
What are the common drug interactions of Copaxone and Cytoxan, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Alopecia (absence of hair from areas of the body)
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Muscle spasms (muscle contraction)
- Abdominal discomfort
- Abdominal pain upper
- Burning sensation
- Chest discomfort
- Diarrhoea
- Drug ineffective
- Mobility decreased (ability to move is reduced)
40-49:
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
- Gingival erosion (gum ulcer)
- Gingival oedema (swelling of gums)
- Haematoma (collection of blood outside the blood vessels)
- Haematuria (presence of blood in urine)
- Headache (pain in head)
- Hepatic lesion
- Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
- Hilar lymphadenopathy (disease of the lymph nodes due to infection)
- Hot flush (sudden feelings of heat)
50-59:
- Hypertension (high blood pressure)
- Optic neuritis (optic nerve inflammation)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Peroneal nerve palsy
60+:
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Joint range of motion decreased (disease of joint movement)
- Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
- Mobility decreased (ability to move is reduced)
- Muscle contracture (a permanent shortening of a muscle)
- Muscle tightness
- Muscular weakness (muscle weakness)
- Myalgia (muscle pain)
- Myopathy (a muscular disease in which the muscle fibres do not function)
What are the existing conditions these people have? *
- Breast Cancer Female: 5 people, 17.86%
- Nuclear Magnetic Resonance Imaging Brain: 2 people, 7.14%
- High Blood Pressure: 2 people, 7.14%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.14%
* Approximation only. Some reports may have incomplete information.
Do you take Copaxone and Cytoxan?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Copaxone and Cytoxan:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Copaxone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cytoxan:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Copaxone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cytoxan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Michaud CJ, Bockheim HM, Nabeel M, Daum TE, "Diagnosis of Exclusion: A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis", Case reports in neurological medicine, 2014 Jul .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Michaud CJ, Bockheim HM, Nabeel M, Daum TE, "Diagnosis of Exclusion: A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis", Case reports in neurological medicine, 2014 Jul .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
How the study uses the data?
The study uses data from the FDA. It is based on glatiramer acetate and cyclophosphamide (the active ingredients of Copaxone and Cytoxan, respectively), and Copaxone and Cytoxan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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