Cordarone and Aredia drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Cordarone (amiodarone hydrochloride) and Aredia (pamidronate disodium). Common drug interactions include pleural effusion among females and general physical health deterioration among males.
The phase IV clinical study analyzes what interactions people have when they take Cordarone and Aredia. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.
What is Cordarone?
Cordarone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 22,776 Cordarone users. Check the latest studies of Cordarone.
What is Aredia?
Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,364 Aredia users. Check the latest studies of Aredia.
45 people who take Cordarone and Aredia together, and have interactions are studied.

What are the common drug interactions of Cordarone and Aredia, by gender? *:
female:
- Pleural effusion (water on the lungs)
- Adrenal mass
- Anaemia (lack of blood)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Arteriosclerosis (thickening and hardening of arteries)
- Arthralgia (joint pain)
- Asthenia (weakness)
- Cardiac failure congestive
- Cardiomegaly (increased size of heart than normal)
male:
- General physical health deterioration (weak health status)
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
- Anxiety
- Atelectasis (partial or complete collapse of the lung)
- Bacteraemia (presence of bacteria in the blood)
- Benign prostatic hyperplasia (benign enlargement of the prostate)
- Cardiomegaly (increased size of heart than normal)
- Cataract (clouding of the lens inside the eye)
- Compression fracture (fracture due to pressure caused by injury)
- Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
What are the common drug interactions of Cordarone and Aredia, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Back pain
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Septic shock (shock due to blood infection)
50-59:
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Asthenia (weakness)
- Atelectasis (partial or complete collapse of the lung)
- Atrioventricular block first degree (heart block first degree)
- Bacteraemia (presence of bacteria in the blood)
- Basosquamous carcinoma (metatypical basal cell cancer)
- Benign prostatic hyperplasia (benign enlargement of the prostate)
- Blepharitis (chronic inflammation of the eyelid)
- Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
- Bone pain
60+:
- Anaemia (lack of blood)
- Pyrexia (fever)
- Cardiomegaly (increased size of heart than normal)
- Injury
- Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
- Mitral valve incompetence (inefficient heart valve)
- Renal failure (kidney dysfunction)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Type 2 diabetes mellitus
- Contusion (a type of hematoma of tissue in which capillaries)
What are the existing conditions these people have? *
- Osteoporosis (bones weak and more likely to break): 17 people, 37.78%
- Bone Loss: 16 people, 35.56%
- High Blood Pressure: 13 people, 28.89%
- Hyperkalemia (damage to or disease of the kidney): 7 people, 15.56%
- Stress And Anxiety: 6 people, 13.33%
- Hypercalcaemia (elevated calcium (ca+) level in the blood): 6 people, 13.33%
- Diabetes: 6 people, 13.33%
- Pain: 5 people, 11.11%
- Multiple Myeloma (cancer of the plasma cells): 5 people, 11.11%
- Anaemia (lack of blood): 5 people, 11.11%
* Approximation only. Some reports may have incomplete information.
Do you take Cordarone and Aredia?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Cordarone and Aredia:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Cordarone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Aredia:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cordarone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Aredia and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .
- Kim DJ, Lee SC, Park GS, Kim GJ, Hwang WT, Lee CS, Lee MH, Hahn DH, Koh HC, "Amiodarone Induced Multiorgan Toxicity in a Patient of Hypertrophic Cardiomyopathy With Atrial Fibrillation", Journal of the Korean Geriatrics Society, 2013 Dec .
- Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .
- Kim DJ, Lee SC, Park GS, Kim GJ, Hwang WT, Lee CS, Lee MH, Hahn DH, Koh HC, "Amiodarone Induced Multiorgan Toxicity in a Patient of Hypertrophic Cardiomyopathy With Atrial Fibrillation", Journal of the Korean Geriatrics Society, 2013 Dec .
How the study uses the data?
The study uses data from the FDA. It is based on amiodarone hydrochloride and pamidronate disodium (the active ingredients of Cordarone and Aredia, respectively), and Cordarone and Aredia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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