Cortef and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include malaise among females.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Macrobid. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jun, 02, 2026

19 people who take Cortef and Macrobid together, and have interactions are studied.

What are the common drug interactions of Cortef and Macrobid, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
C-reactive protein increased
Head discomfort
Influenza
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Oral pruritus (itching in mouth)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Throat irritation
Viral infection

male:

n/a

What are the common drug interactions of Cortef and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Gallbladder operation
Hospitalisation

20-29:

n/a

30-39:

n/a

40-49:

Blood glucose fluctuation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Communication disorder (speech and language disorder)
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fatigue (feeling of tiredness)
Headache (pain in head)
Injection site bruising
Migraine (headache)
Oropharyngeal pain

50-59:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abscess (pus)
C-reactive protein increased
Dyspnoea (difficult or laboured respiration)
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Abdominal discomfort
Ageusia (loss of taste functions of the tongue)
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anosmia (partial or complete loss of the sense of smell)

60+:

Bacterial infection
C-reactive protein increased
Malaise (a feeling of general discomfort or uneasiness)
Oral pruritus (itching in mouth)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Throat irritation
Viral infection
White blood cell count increased
Blood pressure increased

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 26.32%
Itching: 4 people, 21.05%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 15.79%
Depression: 3 people, 15.79%
Nausea And Vomiting: 3 people, 15.79%
Stress Urinary Incontinence (leak urine with things like coughing, sneezing or exercise): 2 people, 10.53%
Constipation: 2 people, 10.53%
Essential Hypertension (primary hypertension): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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