Cortef and Megace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Megace (megestrol acetate). Common drug interactions include abdominal pain among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Megace. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

On Aug, 08, 2026

20 people who take Cortef and Megace together, and have interactions are studied.

What are the common drug interactions of Cortef and Megace, by gender? *:

female:

Abdominal pain
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fall
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Septic shock (shock due to blood infection)
Vomiting
Cardiac failure acute

male:

Fatigue (feeling of tiredness)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Impaired healing
Lactic acidosis (low ph in body tissues)
Renal cell carcinoma (a kidney cancer)
Respiratory disorder (respiratory disease)
Secondary adrenocortical insufficiency (inadequate secretion of acth by the pituitary gland)

What are the common drug interactions of Cortef and Megace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)

20-29:

Gait disturbance

30-39:

Confusional state
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Nausea (feeling of having an urge to vomit)
Septic shock (shock due to blood infection)
Vomiting
Cardiac failure acute
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

40-49:

n/a

50-59:

Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)
Obstructive uropathy (a blockage that prevents urine from leaving your kidneys)
Oedema (fluid collection in tissue)
Orbital oedema (swelling of orbit)
Osteonecrosis of jaw (death of bone of jaw)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Coagulopathy (blood's ability to clot is impaired)
Impaired healing
Lactic acidosis (low ph in body tissues)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal cell carcinoma (a kidney cancer)
Secondary adrenocortical insufficiency (inadequate secretion of acth by the pituitary gland)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Acute pulmonary oedema (sudden deposit of fluid in the lung))

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 25.00%
Nausea And Vomiting: 4 people, 20.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 15.00%
Dry Eyes (lack of adequate tears): 3 people, 15.00%
Diarrhea: 3 people, 15.00%
Pain: 3 people, 15.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 15.00%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 3 people, 15.00%
Stress And Anxiety: 3 people, 15.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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