Cortef and Questran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Questran (cholestyramine). Common drug interactions include breast cancer recurrent among females and abscess rupture among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Questran. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Questran?

Questran has active ingredients of cholestyramine. It is often used in diarrhea. eHealthMe is studying from 4,490 Questran users. Check the latest studies of Questran.



On Jul, 15, 2026

14 people who take Cortef and Questran together, and have interactions are studied.

Cortef and Questran drug interactions.

What are the common drug interactions of Cortef and Questran, by gender? *:

female:

  1. Breast cancer recurrent
  2. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  3. Costochondritis (chest wall pain)
  4. Disability
  5. Fall
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Gingival infection (gum infection)
  8. Granulomatous liver disease (a mass of inflamed granulation tissue of liver)
  9. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  10. Injury

male:

  1. Abscess rupture (pus release from the point of abscess)
  2. Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)
  3. Bone disorder
  4. Bone fragmentation
  5. Bone marrow granuloma (collection of inflammatory cells in bone marrow)
  6. Breast cancer recurrent
  7. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  8. Central nervous system lymphoma (cancer of central nervous system forms in lymph tissue)
  9. Cholangitis chronic (long lasting infection of the bile duct)
  10. Cholecystitis acute (rapid infection of gallbladder)

What are the common drug interactions of Cortef and Questran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Abortion spontaneous (naturally occurring miscarriage)

40-49:

n/a

50-59:

  1. Asthma
  2. Bacteraemia (presence of bacteria in the blood)
  3. Blood glucose increased
  4. Bone disorder
  5. Bone fragmentation
  6. Bone marrow granuloma (collection of inflammatory cells in bone marrow)
  7. Breast cancer recurrent
  8. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  9. Central nervous system lymphoma (cancer of central nervous system forms in lymph tissue)
  10. Cholangitis chronic (long lasting infection of the bile duct)

60+:

  1. Anaemia (lack of blood)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Fatigue (feeling of tiredness)
  4. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  5. Gingival infection (gum infection)
  6. Granulomatous liver disease (a mass of inflamed granulation tissue of liver)
  7. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  8. Injury
  9. Oedema mouth (swelling of mouth)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
  2. High Blood Pressure: 2 people, 14.29%
  3. Vitamin B12 Deficiency: 1 person, 7.14%
  4. Stress And Anxiety: 1 person, 7.14%
  5. Sinus Congestion (blockage of sinus): 1 person, 7.14%
  6. Insomnia (sleeplessness): 1 person, 7.14%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.14%
  8. Hypokalemia (low potassium): 1 person, 7.14%
  9. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 7.14%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Cortef and Questran?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cortef and Questran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Questran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Questran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and cholestyramine (the active ingredients of Cortef and Questran, respectively), and Cortef and Questran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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