Cortril and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortril (hydrocortisone) and Adcirca (tadalafil). Common drug interactions include platelet count decreased among females and pneumothorax among males.

The phase IV clinical study analyzes what interactions people have when they take Cortril and Adcirca. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Cortril?

Cortril has active ingredients of hydrocortisone. eHealthMe is studying from 1,715 Cortril users. Check the latest studies of Cortril.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 07, 2026

29 people who take Cortril and Adcirca together, and have interactions are studied.

What are the common drug interactions of Cortril and Adcirca, by gender? *:

female:

Platelet count decreased
Pyrexia (fever)
Device related infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Vomiting
Pneumonia
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Cardiac failure
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Back pain

male:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Right ventricular failure (right half of the heart fails to work)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hyperthyroidism (over activity of the thyroid gland)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Rash
Syncope (loss of consciousness with an inability to maintain postural tone)
Injection site pruritus (severe itching at injection site)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injection site erythema (redness at injection site)

What are the common drug interactions of Cortril and Adcirca, by age (0-1 to 60+)? *:

0-1:

Injection site pruritus (severe itching at injection site)
Lymphadenopathy (disease or enlargement of lymph nodes)
Diarrhoea
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site swelling
Catheter site swelling
Infection
Injection site induration

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pyrexia (fever)
Device related infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Vomiting
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Back pain
Decreased appetite
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pain

40-49:

n/a

50-59:

n/a

60+:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Iron deficiency anaemia
Platelet count decreased
Chest pain
Lymphadenopathy (disease or enlargement of lymph nodes)
Right ventricular failure (right half of the heart fails to work)
Cellulitis (infection under the skin)
General physical health deterioration (weak health status)
Iron deficiency
Pneumonia

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 26 people, 89.66%
Insomnia (sleeplessness): 15 people, 51.72%
Anaemia (lack of blood): 12 people, 41.38%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 12 people, 41.38%
Type 2 Diabetes: 8 people, 27.59%
Langerhans' Cell Histiocytosis: 7 people, 24.14%
Diarrhea: 7 people, 24.14%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 7 people, 24.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.24%
High Blood Pressure: 5 people, 17.24%

* Approximation only. Some reports may have incomplete information.

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