Cosentyx and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosentyx (secukinumab) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include psoriasis among females and gastric cancer among males.

The phase IV clinical study analyzes what interactions people have when they take Cosentyx and Avalide. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cosentyx?

Cosentyx has active ingredients of secukinumab. It is often used in psoriatic arthritis. eHealthMe is studying from 187,247 Cosentyx users. Check the latest studies of Cosentyx.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Jul, 25, 2026

12 people who take Cosentyx and Avalide together, and have interactions are studied.

What are the common drug interactions of Cosentyx and Avalide, by gender? *:

female:

Psoriasis (immune-mediated disease that affects the skin)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Device failure
Abdominal pain
Constipation
Drug effect decreased
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

male:

Gastric cancer (stomach cancer)
Lung neoplasm malignant (cancer tumour of lung)
Weight decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Neoplasm malignant (cancer tumour)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Vocal cord thickening
Laryngeal cancer (cancer of the larynx)

What are the common drug interactions of Cosentyx and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Psoriasis (immune-mediated disease that affects the skin)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Drug effect decreased
Lymphadenopathy (disease or enlargement of lymph nodes)

60+:

Gastric cancer (stomach cancer)
Lung neoplasm malignant (cancer tumour of lung)
Weight decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Neoplasm malignant (cancer tumour)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Vocal cord thickening
Laryngeal cancer (cancer of the larynx)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 8 people, 66.67%
Pain: 2 people, 16.67%
Blood Pressure Abnormal: 2 people, 16.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
Irritable Bowel Syndrome: 1 person, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 8.33%
Diabetes: 1 person, 8.33%
Birth Control: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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