Cosmegen and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosmegen (dactinomycin) and Zofran (ondansetron hydrochloride). Common drug interactions include abdominal distension among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Cosmegen and Zofran. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Cosmegen?

Cosmegen has active ingredients of dactinomycin. eHealthMe is studying from 937 Cosmegen users. Check the latest studies of Cosmegen.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 11, 2026

13 people who take Cosmegen and Zofran together, and have interactions are studied.

What are the common drug interactions of Cosmegen and Zofran, by gender? *:

female:

Abdominal distension
Blood calcium decreased
Blood magnesium decreased
Blood phosphorus decreased
Blood sodium decreased
Cardiomegaly (increased size of heart than normal)
Demyelinating polyneuropathy (disorder that affects the nerves outside of the brain and spinal cord (peripheral nerves))
Depressed mood
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Febrile neutropenia (fever with reduced white blood cells)

male:

Cardiac failure
Immunodeficiency
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Hepatitis (inflammation of the liver)
Histiocytosis haematophagic
Pleural effusion (water on the lungs)
Venoocclusive liver disease (small veins in the liver are obstructed)

What are the common drug interactions of Cosmegen and Zofran, by age (0-1 to 60+)? *:

0-1:

Histiocytosis haematophagic
Pleural effusion (water on the lungs)
Venoocclusive liver disease (small veins in the liver are obstructed)

2-9:

Pain
Cardiac failure

10-19:

Demyelinating polyneuropathy (disorder that affects the nerves outside of the brain and spinal cord (peripheral nerves))
Febrile neutropenia (fever with reduced white blood cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Stomatitis (inflammation of mucous membrane of mouth)

20-29:

Blood calcium decreased
Blood magnesium decreased
Blood phosphorus decreased
Blood sodium decreased
Hypokalaemia (low potassium)

30-39:

Immunodeficiency
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 6 people, 46.15%
Wilms Tumor (cancer of the kidneys that typically occurs in children): 1 person, 7.69%
Ewing's Sarcoma (malignant small, round, blue cell tumour): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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