Cosopt and Amitriptyline hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Amitriptyline hydrochloride (amitriptyline hydrochloride). Common drug interactions include drug ineffective among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Amitriptyline hydrochloride. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

On Jul, 15, 2026

15 people who take Cosopt and Amitriptyline hydrochloride together, and have interactions are studied.

Cosopt and Amitriptyline hydrochloride drug interactions.

What are the common drug interactions of Cosopt and Amitriptyline Hydrochloride, by gender? *:

female:

Drug ineffective
Anaemia (lack of blood)
Faeces discoloured
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypersensitivity
Choroidal detachment (separation of vascular layer of the eye)
Conjunctival bleb (blister of eye covering)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Disease progression

male:

Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Skin irritation
Muscular weakness (muscle weakness)
Respiratory disorder (respiratory disease)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Muscle atrophy (a decrease in the mass of the muscle)
Respiratory failure (inadequate gas exchange by the respiratory system)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis allergic (inflammation of the skin due allergic reaction)

What are the common drug interactions of Cosopt and Amitriptyline Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

60+:

Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Respiratory failure (inadequate gas exchange by the respiratory system)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypersensitivity
Choroidal detachment (separation of vascular layer of the eye)
Conjunctival bleb (blister of eye covering)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Disease progression

What are the existing conditions these people have? *

High Blood Cholesterol: 5 people, 33.33%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 4 people, 26.67%
Lower Respiratory Tract Infection: 4 people, 26.67%
Urinary Tract Infection: 2 people, 13.33%
Prostatic Adenoma (prostatic non-cancerous tumour): 2 people, 13.33%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 2 people, 13.33%
Rashes (redness): 1 person, 6.67%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 1 person, 6.67%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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