Cosopt and Diclofenac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Diclofenac (diclofenac). Common drug interactions include fatigue among females and duodenal ulcer among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Diclofenac. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Diclofenac?

Diclofenac has active ingredients of diclofenac. eHealthMe is studying from 41,319 Diclofenac users. Check the latest studies of Diclofenac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

25 people who take Cosopt and Diclofenac together, and have interactions are studied.

Cosopt and Diclofenac drug interactions.

What are the common drug interactions of Cosopt and Diclofenac, by gender? *:

female:

Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypersensitivity
Exostosis (formation of new bone on the surface of a bone)
Foot deformity (functional disability of foot)
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Muscular weakness (muscle weakness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Abdominal pain

male:

Duodenal ulcer
Melaena (the passage of black, tarry stools)
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Lactic acidosis (low ph in body tissues)
Weight increased
Blood glucose increased
Blood triglycerides increased
Chronic kidney disease
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)

What are the common drug interactions of Cosopt and Diclofenac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Diarrhoea
Influenza like illness
Ligament sprain (ligament stretched)
Liver disorder (liver diseases)
Mobility decreased (ability to move is reduced)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

20-29:

n/a

30-39:

Ear infection
Herpes zoster oticus (viral infection of the inner, middle, and external ear caused by varicella-zoster virus (vzv))
Hypersensitivity

40-49:

Exostosis (formation of new bone on the surface of a bone)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Foot deformity (functional disability of foot)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Muscular weakness (muscle weakness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Asthenia (weakness)

50-59:

n/a

60+:

Duodenal ulcer
Melaena (the passage of black, tarry stools)
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disease progression
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 24.00%
Joint Pain: 5 people, 20.00%
High Blood Pressure: 5 people, 20.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 16.00%
Multiple Myeloma (cancer of the plasma cells): 4 people, 16.00%
High Blood Cholesterol: 3 people, 12.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 8.00%
Migraine (headache): 2 people, 8.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.00%
Depression: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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