Cosopt and Nuplazid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Nuplazid (pimavanserin tartrate). Common drug interactions include insomnia among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Cosopt and Nuplazid. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

On Jul, 06, 2026

23 people who take Cosopt and Nuplazid together, and have interactions are studied.

What are the common drug interactions of Cosopt and Nuplazid, by gender? *:

female:

Insomnia (sleeplessness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Communication disorder (speech and language disorder)
Constipation
Fatigue (feeling of tiredness)
Hypersexuality
Hypokinesia (decreased bodily movement)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nonspecific reaction (unspecified reaction)
Restless legs syndrome (a powerful urge to move your legs)

male:

Hallucination (an experience involving the perception of something not present)
Drug ineffective
Screaming (a long loud piercing cry)
Parkinson's disease
Delusion (a false belief or opinion)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dysphagia (a condition in which swallowing is difficult or painful)
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)
Death

What are the common drug interactions of Cosopt and Nuplazid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Confusional state
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Nonspecific reaction (unspecified reaction)
Parkinson's disease
Poor quality sleep
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Hallucination (an experience involving the perception of something not present)
Fatigue (feeling of tiredness)
Screaming (a long loud piercing cry)
Sleep disorder
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Communication disorder (speech and language disorder)
Constipation
Hypersexuality
Hypokinesia (decreased bodily movement)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the existing conditions these people have? *

Hallucinations (sensations that appear real but are created by your mind): 20 people, 86.96%
Delusion (a false belief or opinion): 19 people, 82.61%
Parkinson's Disease: 11 people, 47.83%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 13.04%
Post Procedural Hypothyroidism: 3 people, 13.04%
Eye Disorder: 3 people, 13.04%
Bone Formation Decreased: 3 people, 13.04%
Blood Pressure Abnormal: 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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