Cotrim and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Amaryl (glimepiride). Common drug interactions include bronchopneumonia among females and blood urea increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Amaryl. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Jul, 18, 2026

39 people who take Cotrim and Amaryl together, and have interactions are studied.

What are the common drug interactions of Cotrim and Amaryl, by gender? *:

female:

Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Asthma
Hyperglycaemia (high blood sugar)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Tremor (trembling or shaking movements in one or more parts of your body)
Disease progression

male:

Blood urea increased
Platelet count decreased
Herpes zoster
Myopathy (a muscular disease in which the muscle fibres do not function)
Ulnar neuritis (inflammation or compression of the ulnar nerve)
Urinary tract infection
C-reactive protein increased
Erythema multiforme (a type of hypersensitivity reaction)
Fall
Gangrene (body tissue dies)

What are the common drug interactions of Cotrim and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anal abscess
Blood creatinine increased
Blood urea increased
Constipation
Electrocardiogram poor r-wave progression
Myopathy (a muscular disease in which the muscle fibres do not function)
Pyrexia (fever)
Ulnar neuritis (inflammation or compression of the ulnar nerve)

50-59:

Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Gangrene (body tissue dies)
Purulence (containing pus)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Multi-organ failure (multisystem organ failure)
Pneumonia

60+:

Platelet count decreased
Herpes zoster
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Neoplasm progression (growth of tumour)
Rash
Subdural haematoma (blood collects between the skull and the surface of the brain)
Acute myocardial infarction (acute heart attack)
Asthma
Brain contusion (a form of traumatic brain injury)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 20.51%
Osteoporosis (bones weak and more likely to break): 7 people, 17.95%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 6 people, 15.38%
Multiple Myeloma (cancer of the plasma cells): 6 people, 15.38%
Constipation: 4 people, 10.26%
Cerebrovascular Disorder (disease of brain): 3 people, 7.69%
Enlarged Prostate: 3 people, 7.69%
Type 2 Diabetes: 3 people, 7.69%
Seronegative Arthritis (a joint disease negative for rheumatoid arthritis): 3 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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