Cotrim and Celebrex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Celebrex (celecoxib). Common drug interactions include nodal arrhythmia among females and bone disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Celebrex. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Celebrex?

Celebrex has active ingredients of celecoxib. It is often used in arthritis. eHealthMe is studying from 151,105 Celebrex users. Check the latest studies of Celebrex.

On Jul, 24, 2026

34 people who take Cotrim and Celebrex together, and have interactions are studied.

What are the common drug interactions of Cotrim and Celebrex, by gender? *:

female:

Nodal arrhythmia (an irregular heart beat originating from within the atrioventricular node)
Ventricular extrasystoles (premature cardiac contraction)
Arthralgia (joint pain)
Cardioactive drug level increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Muscle cramps (painful sensations caused by muscle contraction)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

male:

Bone disorder
Constipation
Dyspnoea (difficult or laboured respiration)
Osteonecrosis of jaw (death of bone of jaw)
Diarrhoea
Dry skin
Dysgeusia (disorder of the sense of taste)
Hypoaesthesia (reduced sense of touch or sensation)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Cotrim and Celebrex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Muscle cramps (painful sensations caused by muscle contraction)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cellulitis (infection under the skin)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased interest
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dysphemia (stammering or stuttering)
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

60+:

Chest pain
Bradycardia (abnormally slow heart action)
Atrioventricular block complete (heart block complete)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bone disorder
Cardiac murmur (an heart sound in valve abnormality)
Constipation
Cough
Depression
Diarrhoea

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 16 people, 47.06%
High Blood Pressure: 14 people, 41.18%
Diarrhea: 13 people, 38.24%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 12 people, 35.29%
Mood Swings (an extreme or rapid change in mood): 12 people, 35.29%
Joint Pain: 12 people, 35.29%
High Blood Cholesterol: 12 people, 35.29%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 35.29%
Seasonal Allergy (allergic condition due to certain season): 6 people, 17.65%
Blood Triglycerides Decreased: 6 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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