Cotrim and Prevacid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Prevacid (lansoprazole). Common drug interactions include depression among females and renal injury among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Prevacid. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Prevacid?

Prevacid has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 130,714 Prevacid users. Check the latest studies of Prevacid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

17 people who take Cotrim and Prevacid together, and have interactions are studied.

What are the common drug interactions of Cotrim and Prevacid, by gender? *:

female:

Depression
Dry skin
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic cyst
Inflammatory bowel disease
Irritable bowel syndrome
Lumbar radiculopathy (radicular pain in the low back and legs)
Mouth cyst (a fluid filled sac in mouth)
Myalgia (muscle pain)
Myositis (inflammation of the muscles)

male:

Renal injury (kidney injury)
Chronic kidney disease
Asthma
Back pain
Blood creatine phosphokinase increased
Blood creatine phosphokinase mb increased
Blood glucose fluctuation
Blood phosphorus decreased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Cotrim and Prevacid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Muscle cramps (painful sensations caused by muscle contraction)

20-29:

Adenoma benign (non-cancerous tumour -secreting)
Adnexa uteri mass (ovarian cysts)
Back pain
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Dry skin
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic cyst

30-39:

n/a

40-49:

Anastomotic leak
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Coma (state of unconsciousness lasting more than six hours)
Haematocrit decreased
Haemoglobin decreased
Haemorrhage (bleeding)
Hepatic artery thrombosis (formation of a blood clot inside a hepatic artery)
Hypotension (abnormally low blood pressure)
International normalised ratio increased

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Renal failure (kidney dysfunction)
Rib fracture
Weight increased
Anaemia (lack of blood)
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aphthous stomatitis (mouth ulcer)
Arteriosclerosis (thickening and hardening of arteries)
Asthma

60+:

Disease progression
Injury
Metastases to central nervous system (cancer spreads to central nervous system)
Pain
Rash generalised (rash on most of body parts)
Rash pruritic (redness with itching)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Premenstrual Syndrome: 2 people, 11.76%
Acne (skin problems that cause pimples): 2 people, 11.76%
Birth Control: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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