Cotrim and Ursodiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Ursodiol (ursodiol). Common drug interactions include respiratory tract haemorrhage among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Ursodiol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

On Jul, 15, 2026

41 people who take Cotrim and Ursodiol together, and have interactions are studied.

What are the common drug interactions of Cotrim and Ursodiol, by gender? *:

female:

Respiratory tract haemorrhage (respiratory tract bleeding)
Secretion discharge
Sputum increased
Abdominal distension
Abdominal pain
Actinic keratosis (skin disease due to sun exposure)
Angiopathy (generic term for a disease of the blood vessels)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anti-hbc igg antibody positive
Asterixis (flapping tremor, or liver flap)

male:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Cerebral haemorrhage (bleeding within the brain)
Hemianopia (blindness or reduction in vision in one half of the visual field due to damage of the optic pathways in the brain)
Hemiparesis (weakness on one side of the body)
Hypotension (abnormally low blood pressure)
Persecutory delusion
Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase increased
Aspartate aminotransferase increased

What are the common drug interactions of Cotrim and Ursodiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Acute respiratory distress syndrome
Anaphylactic reaction (serious allergic reaction)
Diarrhoea
Drug level increased
Gastrointestinal candidiasis (fungal infection of gastrointestinal tract)
Infection in an immunocompromised host
Liver disorder (liver diseases)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia aspergillus (invasive type is a serious infection with pneumonia that can spread to other parts of the body)

10-19:

Abdominal pain
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Death
Diarrhoea
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Epstein-barr viraemia
Graft versus host disease in intestine (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body and damages intestinal mucosal membrane)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)

20-29:

Headache (pain in head)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Oral candidiasis (fungal infection of mouth)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Vomiting

30-39:

Pneumonia fungal
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Rash
Respiratory tract haemorrhage (respiratory tract bleeding)
Secretion discharge
Sputum increased
Angiopathy (generic term for a disease of the blood vessels)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

Gait disturbance
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Aggression
Agitation (state of anxiety or nervous excitement)
Blood pressure increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cerebral haemorrhage (bleeding within the brain)
Hemianopia (blindness or reduction in vision in one half of the visual field due to damage of the optic pathways in the brain)
Hemiparesis (weakness on one side of the body)

50-59:

Actinic keratosis (skin disease due to sun exposure)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dysplasia (enlargement of an organ or tissue)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Skin cancer

60+:

Hepatitis b
Hepatic failure (liver failure)
Anti-hbc igg antibody positive
Ascites (accumulation of fluid in the abdominal cavity)
Asterixis (flapping tremor, or liver flap)
Cytomegalovirus infection
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disease recurrence
Febrile neutropenia (fever with reduced white blood cells)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 9 people, 21.95%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 8 people, 19.51%
Fungal Infection: 4 people, 9.76%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 3 people, 7.32%
Pain: 3 people, 7.32%
Infection: 3 people, 7.32%
Hiv Infection: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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