Coumadin and Samsca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coumadin (warfarin sodium) and Samsca (tolvaptan). Common drug interactions include oedema peripheral among females and blood sodium decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Coumadin and Samsca. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

16 people who take Coumadin and Samsca together, and have interactions are studied.

What are the common drug interactions of Coumadin and Samsca, by gender? *:

female:

Oedema peripheral (superficial swelling)
Cellulitis (infection under the skin)
Femur fracture
Weight decreased
Blood sodium decreased
Fluid retention (an abnormal accumulation of fluid in the blood)
Oxygen saturation decreased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Cardiac failure

male:

Blood sodium decreased
Confusional state
Inappropriate antidiuretic hormone secretion
Renal impairment (severely reduced kidney function)
Acute hepatic failure
Acute respiratory failure
Cardiac arrest
Cardiac disorder
Cardiac failure
Cardiac failure congestive

What are the common drug interactions of Coumadin and Samsca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac failure
Hepatic enzyme increased

40-49:

n/a

50-59:

Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Syncope (loss of consciousness with an inability to maintain postural tone)
Alcohol induced persisting dementia
Inappropriate antidiuretic hormone secretion

60+:

Oedema peripheral (superficial swelling)
Blood sodium decreased
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Cardiac arrest
Cardiac disorder
Cardiac failure
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Eating disorder

What are the existing conditions these people have? *

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 7 people, 43.75%
Blood Sodium Decreased: 3 people, 18.75%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 18.75%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 12.50%
Stress And Anxiety: 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Cardiac Failure Congestive: 1 person, 6.25%
Diabetes: 1 person, 6.25%
Essential Hypertension (primary hypertension): 1 person, 6.25%
Fungal Nail Infection: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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