Coumadin and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coumadin (warfarin sodium) and Savella (milnacipran hydrochloride). Common drug interactions include drug ineffective among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Coumadin and Savella. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

71 people who take Coumadin and Savella together, and have interactions are studied.

What are the common drug interactions of Coumadin and Savella, by gender? *:

female:

Drug ineffective
Drug intolerance (drug sensitivity)
Dysarthria (speech disorder)
Dyspepsia (indigestion)
Epistaxis (bleed from the nose)
Feeling jittery
Haematochezia (passage of stools containing blood)
Head injury
Herpes zoster
Hyperlipidaemia (presence of excess lipids in the blood)

male:

Arthralgia (joint pain)
International normalised ratio increased
Contusion (a type of hematoma of tissue in which capillaries)
Dry mouth
Dyspepsia (indigestion)
Dysuria (painful or difficult urination)
Gait disturbance
Gastrointestinal motility disorder (abnormal intestinal contractions)
Haemorrhage (bleeding)
Hypersomnia (excessive daytime sleepiness (eds))

What are the common drug interactions of Coumadin and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cellulitis (infection under the skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Hysterectomy
Migraine (headache)
Pulmonary embolism (blockage of the main artery of the lung)
Scotoma (an area of diminished vision within the visual field)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Thrombosis (formation of a blood clot inside a blood vessel)
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased

50-59:

Arthralgia (joint pain)
Headache (pain in head)
Homicidal ideation (thoughts about human killing another human)
International normalised ratio increased
Joint injury
Nasal cyst (air or fluid filled sac of nose)
Sinusitis (inflammation of sinus)
Tremor (trembling or shaking movements in one or more parts of your body)
Disturbance in attention
Dizziness

60+:

Fall
Peripheral swelling
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Abdominal distension
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 8.45%
Stress And Anxiety: 5 people, 7.04%
Pain: 5 people, 7.04%
Neuropathy Peripheral (surface nerve damage): 5 people, 7.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.04%
Immune System Disorder: 4 people, 5.63%
Drowsiness: 4 people, 5.63%
Depression: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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