Cozaar and Metrogel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cozaar (losartan potassium) and Metrogel (metronidazole). Common drug interactions include hallucination among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Cozaar and Metrogel. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.



On Jul, 08, 2026

43 people who take Cozaar and Metrogel together, and have interactions are studied.

Cozaar and Metrogel drug interactions.

What are the common drug interactions of Cozaar and Metrogel, by gender? *:

female:

  1. Hallucination (an experience involving the perception of something not present)
  2. Hemiplegia (paralysis of one side of the body)
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  4. Infection
  5. Insomnia (sleeplessness)
  6. Irritability
  7. Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
  8. Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
  9. Memory impairment
  10. Milk allergy

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Headache (pain in head)
  3. Ocular rosacea (redness, irritation or burning of the eyes)
  4. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  5. Weight increased
  6. Depression
  7. Dry eye (lack of adequate tears)
  8. Exercise tolerance decreased
  9. Fatigue (feeling of tiredness)
  10. Hypotension (abnormally low blood pressure)

What are the common drug interactions of Cozaar and Metrogel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)

50-59:

  1. Alopecia (absence of hair from areas of the body)
  2. Hair colour changes
  3. Hair disorder
  4. Anxiety
  5. Chronic kidney disease
  6. Depression
  7. Emotional distress
  8. Fatigue (feeling of tiredness)
  9. Headache (pain in head)
  10. Hyperglycaemia (high blood sugar)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Blood creatine phosphokinase increased
  3. Speech disorder
  4. Diaphragmatic disorder
  5. Fall
  6. Myalgia (muscle pain)
  7. Abdominal distension
  8. Abdominal pain
  9. Alanine aminotransferase increased
  10. Blood bilirubin increased

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 12 people, 27.91%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 23.26%
  3. High Blood Cholesterol: 10 people, 23.26%
  4. Restless Leg Syndrome (a powerful urge to move your legs): 9 people, 20.93%
  5. Nausea (feeling of having an urge to vomit): 8 people, 18.60%
  6. Wheezing (a high-pitched whistling sound made while you breath): 6 people, 13.95%
  7. Nausea And Vomiting: 6 people, 13.95%
  8. Cellulitis (infection under the skin): 6 people, 13.95%
  9. Hypokalemia (low potassium): 6 people, 13.95%
  10. Neoplasm Malignant (cancer tumour): 6 people, 13.95%

* Approximation only. Some reports may have incomplete information.

Do you take Cozaar and Metrogel?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cozaar and Metrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cozaar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cozaar and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metrogel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on losartan potassium and metronidazole (the active ingredients of Cozaar and Metrogel, respectively), and Cozaar and Metrogel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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