Cryselle and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cryselle (ethinyl estradiol; norgestrel) and Melatonin (melatonin). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Cryselle and Melatonin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Cryselle?

Cryselle has active ingredients of ethinyl estradiol; norgestrel. It is often used in birth control. eHealthMe is studying from 673 Cryselle users. Check the latest studies of Cryselle.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 05, 2026

22 people who take Cryselle and Melatonin together, and have interactions are studied.

Cryselle and Melatonin drug interactions.

What are the common drug interactions of Cryselle and Melatonin, by gender? *:

female:

Headache (pain in head)
Influenza
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Productive cough
Pruritus (severe itching of the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)
Skin infection
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Uterine infection

male:

n/a

What are the common drug interactions of Cryselle and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Crying
Depression
Blood pressure increased
Drug ineffective
Injection site pain
Injection site rash
Injection site swelling
Migraine (headache)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

30-39:

Influenza
Mastitis (inflammation of breast)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oral herpes (viral infection of mouth)
Paranasal sinus discomfort
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Productive cough
Pruritus (severe itching of the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 36.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 31.82%
Immunodeficiency Common Variable: 4 people, 18.18%
Immunodeficiency: 4 people, 18.18%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 9.09%
Migraine (headache): 2 people, 9.09%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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