Cubicin and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cubicin (daptomycin) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include osteonecrosis of jaw among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Cubicin and Spiriva. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Cubicin?

Cubicin has active ingredients of daptomycin. It is often used in infection. eHealthMe is studying from 7,991 Cubicin users. Check the latest studies of Cubicin.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

27 people who take Cubicin and Spiriva together, and have interactions are studied.

What are the common drug interactions of Cubicin and Spiriva, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply)
Osteosclerosis (an elevation in bone density)
Ovarian cyst (fluid filled sac of the ovary)
Pain
Pain in jaw
Pancreatic atrophy
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Panic disorder
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

male:

Arthralgia (joint pain)
C-reactive protein increased
Renal failure acute (rapid kidney dysfunction)
Toxic skin eruption (skin breakdown due to toxic substance)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Dyspnoea (difficult or laboured respiration)
Eosinophil count increased
Eosinophilic pneumonia (eosinophil accumulates in the lung)

What are the common drug interactions of Cubicin and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pancreatitis (inflammation of pancreas)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Sepsis (a severe blood infection that can lead to organ failure and death)
Pneumonia
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Coccidioidomycosis (serious disease of the lungs and other tissues, caused by the fungus coccidioides immitis)
Hepatomegaly (abnormal enlargement of the liver)

50-59:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

60+:

Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Renal failure acute (rapid kidney dysfunction)
Toxic skin eruption (skin breakdown due to toxic substance)
International normalised ratio increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Muscle spasms (muscle contraction)
Abdominal pain
Abscess jaw (tooth abscess or root abscess)
Adjustment disorder

What are the existing conditions these people have? *

Wound Infection: 4 people, 14.81%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 14.81%
High Blood Pressure: 4 people, 14.81%
Skin Infection: 3 people, 11.11%
Diabetes: 3 people, 11.11%
Staphylococcal Bacteraemia (a bacterial infection of blood): 2 people, 7.41%
Pain: 2 people, 7.41%
Endocarditis (inflammation in heart muscle): 2 people, 7.41%
Asthma: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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