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Curcumin and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Curcumin (turmeric) and Keytruda (pembrolizumab). Common drug interactions include arthralgia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Curcumin and Keytruda. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Curcumin?

Curcumin has active ingredients of turmeric. It is often used in inflammation. eHealthMe is studying from 3,677 Curcumin users. Check the latest studies of Curcumin.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

20 people who take Curcumin and Keytruda together, and have interactions are studied.

Curcumin and Keytruda drug interactions.

What are the common drug interactions of Curcumin and Keytruda, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Diarrhoea
  3. Fatigue (feeling of tiredness)
  4. Adverse drug reaction
  5. Aphasia (damage to the parts of the brain that control language)
  6. Back pain
  7. Blindness
  8. Blood potassium decreased
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Cerebral haemorrhage (bleeding within the brain)

male:

  1. Fatigue (feeling of tiredness)
  2. Arthralgia (joint pain)
  3. Hypotension (abnormally low blood pressure)
  4. Nasal discomfort
  5. Oral pain
  6. Stomatitis (inflammation of mucous membrane of mouth)
  7. Weight decreased
  8. Abdominal distension
  9. Abdominal pain
  10. Fracture pain

What are the common drug interactions of Curcumin and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Eyelid irritation
  2. Eyelid skin dryness
  3. Eyelids pruritus (eyelids itching)
  4. Hypersensitivity
  5. Influenza like illness
  6. Sinus disorder (disease of sinus)
  7. Skin exfoliation (removal of the oldest dead skin cells)
  8. Tonsillitis (inflammation of tonsil)

40-49:

n/a

50-59:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Blood pressure increased
  4. Constipation
  5. Dry mouth
  6. Dry skin
  7. Ear disorder
  8. Hip fracture
  9. Hyperaesthesia
  10. Hypotension (abnormally low blood pressure)

60+:

  1. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  2. Diarrhoea
  3. Drug ineffective
  4. Fatigue (feeling of tiredness)
  5. Skin disorder (skin disease)
  6. Skin ulcer
  7. Sluggishness (lacking alertness)
  8. Blood potassium decreased
  9. Dizziness

What are the existing conditions these people have? *

  1. Renal Cancer Metastatic (cancer of kidney spreads to other part): 7 people, 35.00%
  2. Bone Disorder: 7 people, 35.00%
  3. Constipation: 6 people, 30.00%
  4. Endometrial Cancer: 5 people, 25.00%
  5. Lung Cancer - Non-Small Cell (lung cancer): 4 people, 20.00%
  6. Sleep Disorder: 1 person, 5.00%
  7. Renal Cancer Stage Iv (the tumour has spread to areas beyond gerota's fascia and extends into the adrenal gland on the same side of the body as the tumour, possibly to lymph nodes, but not to other parts of the body): 1 person, 5.00%
  8. Pancreatic Carcinoma Stage Iv (pancreatic cancer stage iv): 1 person, 5.00%
  9. Hodgkin's Lymphoma (cancer originating from white blood cells): 1 person, 5.00%
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Curcumin and Keytruda?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Curcumin and Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Curcumin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Keytruda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Curcumin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Keytruda and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on turmeric and pembrolizumab (the active ingredients of Curcumin and Keytruda, respectively), and Curcumin and Keytruda (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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