Curcumin and Silybum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Curcumin (turmeric) and Silybum (milk thistle). Common drug interactions include white blood cell count decreased among females and metal poisoning among males.

The phase IV clinical study analyzes what interactions people have when they take Curcumin and Silybum. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Curcumin?

Curcumin has active ingredients of turmeric. It is often used in inflammation. eHealthMe is studying from 3,676 Curcumin users. Check the latest studies of Curcumin.

What is Silybum?

Silybum has active ingredients of milk thistle. eHealthMe is studying from 779 Silybum users. Check the latest studies of Silybum.

On Aug, 01, 2026

52 people who take Curcumin and Silybum together, and have interactions are studied.

What are the common drug interactions of Curcumin and Silybum, by gender? *:

female:

White blood cell count decreased
Fatigue (feeling of tiredness)
Dizziness
Memory impairment
Anxiety
Drug ineffective
Nausea (feeling of having an urge to vomit)
Dry mouth
Malaise (a feeling of general discomfort or uneasiness)
Oropharyngeal pain

male:

Metal poisoning
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Drug ineffective
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Heart rate decreased
Hepatic enzyme increased

What are the common drug interactions of Curcumin and Silybum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Blood pressure fluctuation
Blood pressure systolic increased
Chills (felling of cold)
Cough
Drug ineffective
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Headache (pain in head)

40-49:

Abdominal discomfort
Anxiety
Autoimmune hepatitis
Autoimmune pancreatitis (autoimmune pancreatitis (aip) is an increasingly recognized type of chronic pancreatitis)
Dizziness
Face injury
Fall
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Ligament sprain (ligament stretched)

50-59:

Interstitial lung disease
Pneumomediastinum (air is present in the mediastinum)
Respiratory failure (inadequate gas exchange by the respiratory system)
Asthenia (weakness)
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Hypertension (high blood pressure)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Death
Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Neck pain
Rash
Vomiting
Weight increased
Balance disorder
Constipation
Cystitis interstitial (unknown cause characterized by bladder pain)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 15.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 15.38%
Nausea And Vomiting: 3 people, 5.77%
Diarrhea: 3 people, 5.77%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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