Cyclobenzaprine hydrochloride and Pyridium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cyclobenzaprine hydrochloride (cyclobenzaprine hydrochloride) and Pyridium (phenazopyridine hydrochloride). Common drug interactions include foot fracture among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Cyclobenzaprine hydrochloride and Pyridium. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Cyclobenzaprine hydrochloride?

Cyclobenzaprine hydrochloride has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 9,352 Cyclobenzaprine hydrochloride users. Check the latest studies of Cyclobenzaprine hydrochloride.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

15 people who take Cyclobenzaprine hydrochloride and Pyridium together, and have interactions are studied.

Cyclobenzaprine hydrochloride and Pyridium drug interactions.

What are the common drug interactions of Cyclobenzaprine Hydrochloride and Pyridium, by gender? *:

female:

Foot fracture
Hospitalisation
Infected cyst
Infusion site reaction
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)
Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Bone disorder

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Diarrhoea
Nephrogenic anaemia (anaemia due to kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the common drug interactions of Cyclobenzaprine Hydrochloride and Pyridium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiac disorder
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Ear infection
Foot fracture
Infected cyst
Infusion site reaction
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hip arthroplasty

60+:

Bone disorder
Chronic kidney disease
Pathological fracture (broken bone caused by disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Fall
Femur fracture
Joint instability (a condition in which the joints aren't sufficiently supported)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)

What are the existing conditions these people have? *

Pain: 6 people, 40.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 33.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 33.33%
Depression: 4 people, 26.67%
Cardiac Disorder: 3 people, 20.00%
Indigestion: 3 people, 20.00%
Immunodeficiency Common Variable: 2 people, 13.33%
Asthma: 2 people, 13.33%
Sinus Disorder (disease of sinus): 2 people, 13.33%
Bladder Disorder: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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