Cyclophosphamide and Endep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cyclophosphamide (cyclophosphamide) and Endep (amitriptyline hydrochloride). Common drug interactions include pyrexia among females and diverticular perforation among males.

The phase IV clinical study analyzes what interactions people have when they take Cyclophosphamide and Endep. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

On Jul, 07, 2026

12 people who take Cyclophosphamide and Endep together, and have interactions are studied.

Cyclophosphamide and Endep drug interactions.

What are the common drug interactions of Cyclophosphamide and Endep, by gender? *:

female:

Pyrexia (fever)
Hepatic failure (liver failure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Syncope (loss of consciousness with an inability to maintain postural tone)
Electrocardiogram qt prolonged
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)

male:

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)
Oral infection

What are the common drug interactions of Cyclophosphamide and Endep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Electrocardiogram qt prolonged

50-59:

n/a

60+:

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)
Hepatic failure (liver failure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Syncope (loss of consciousness with an inability to maintain postural tone)
Oral infection
Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Pyrexia (fever)

What are the existing conditions these people have? *

Back Pain: 9 people, 75.00%
Upper Respiratory Tract Infection: 6 people, 50.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 6 people, 50.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 50.00%
Constipation: 6 people, 50.00%
Enlarged Prostate: 6 people, 50.00%
Febrile Neutropenia (fever with reduced white blood cells): 6 people, 50.00%
Insomnia (sleeplessness): 6 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 50.00%
Nausea (feeling of having an urge to vomit): 6 people, 50.00%

* Approximation only. Some reports may have incomplete information.

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