Cyclophosphamide and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cyclophosphamide (cyclophosphamide) and Pentoxifylline (pentoxifylline). Common drug interactions include respiratory disorder among females and leukopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Cyclophosphamide and Pentoxifylline. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

On Jul, 18, 2026

91 people who take Cyclophosphamide and Pentoxifylline together, and have interactions are studied.

Cyclophosphamide and Pentoxifylline drug interactions.

What are the common drug interactions of Cyclophosphamide and Pentoxifylline, by gender? *:

female:

Respiratory disorder (respiratory disease)
Respiratory failure (inadequate gas exchange by the respiratory system)
Renal impairment (severely reduced kidney function)
Infection
Asthenia (weakness)
Cough
Dizziness
Herpes zoster
Impaired gastric emptying
Left ventricular dysfunction

male:

Leukopenia (less number of white blood cells in blood)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Diastolic dysfunction
Haematuria (presence of blood in urine)
Localised infection (infection at the single location)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Oesophageal dilatation (enlarged oesophagus)
Oral candidiasis (fungal infection of mouth)
Osteoporosis (bones weak and more likely to break)
Pneumonia

What are the common drug interactions of Cyclophosphamide and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Malignant atrophic papulosis (an extremely rare vascular weakness that affects the lining of the medium and small veins and arteries)
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Genital lesion (sores, warts, or blemishes that appear on the genitals)
Haemorrhage (bleeding)
Hoarseness (changing voice)
Multi-organ failure (multisystem organ failure)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Renal failure acute (rapid kidney dysfunction)
Respiratory distress (difficulty in breathing)

20-29:

Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Abdominal pain upper
Drug ineffective
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Respiratory failure (inadequate gas exchange by the respiratory system)
Venoocclusive disease (small veins in the liver are obstructed)
Ascites (accumulation of fluid in the abdominal cavity)
Cranial nerve disorder (impaired functioning of one of the twelve cranial nerves)
Disease progression
Quadriplegia (a four limb paralysis)

30-39:

Abdominal pain upper
Ascites (accumulation of fluid in the abdominal cavity)
Drug ineffective
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Venoocclusive disease (small veins in the liver are obstructed)
Weight increased

40-49:

Asthenia (weakness)
Cough
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Oesophagitis (inflammation of oesophagus)
Vomiting

50-59:

Chest pain
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Interstitial lung disease
Joint abscess (pus in joints due to infection)
Mania (a state of abnormally elevated or irritable mood)
Metastasis (spreadable cancer to other organ from origin)
Mycobacterium abscessus infection (rapid growing bacterial infection)
Polyarteritis nodosa (progressive disease of connective tissue)
Pneumonia
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Creatinine renal clearance decreased
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Malaise (a feeling of general discomfort or uneasiness)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cytomegalovirus retinitis (retina infection with cytomegalo virus)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Endocarditis (inflammation in heart muscle)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Exanthem (rashes on skin by viral infection)

What are the existing conditions these people have? *

Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 26 people, 28.57%
Interstitial Lung Disease: 17 people, 18.68%
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls): 15 people, 16.48%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 12 people, 13.19%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 9.89%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 7 people, 7.69%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 6.59%
Gastric Disorder (disease of stomach): 6 people, 6.59%
Primary Amyloidosis (disease that occurs when substances called amyloid proteins build up in your organs): 5 people, 5.49%
Malignant Atrophic Papulosis (an extremely rare vascular weakness that affects the lining of the medium and small veins and arteries): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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