Cyclophosphamide and Zyvox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cyclophosphamide (cyclophosphamide) and Zyvox (linezolid). Common drug interactions include metabolic acidosis among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Cyclophosphamide and Zyvox. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

On Jul, 09, 2026

45 people who take Cyclophosphamide and Zyvox together, and have interactions are studied.

Cyclophosphamide and Zyvox drug interactions.

What are the common drug interactions of Cyclophosphamide and Zyvox, by gender? *:

female:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Oedema (fluid collection in tissue)
Renal failure (kidney dysfunction)
Vomiting
Candidiasis (candidiasis or thrush is a fungal infection)
Multi-organ failure (multisystem organ failure)
Platelet count decreased
Pyrexia (fever)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Adenoviral haemorrhagic cystitis
Anaemia (lack of blood)
Blood bilirubin increased
Platelet count decreased
Pneumonia adenoviral (viral pneumonia caused by an adenovirus)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)

What are the common drug interactions of Cyclophosphamide and Zyvox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Sepsis (a severe blood infection that can lead to organ failure and death)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Abdominal pain
Neutropenia (an abnormally low number of neutrophils)
Somnolence (a state of near-sleep, a strong desire for sleep)
Agitation (state of anxiety or nervous excitement)
Depressed level of consciousness
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Irritability
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

10-19:

Anaemia (lack of blood)
Hypokalaemia (low potassium)
White blood cell count decreased
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Hypoproteinaemia (too little prolactin circulating in the blood)
Sepsis (a severe blood infection that can lead to organ failure and death)

20-29:

Renal failure (kidney dysfunction)
Abdominal pain
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Vomiting
Catheter related infection
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Pyrexia (fever)
Brain stem haemorrhage (bleeding into structures of brain stem)

30-39:

Sinusitis (inflammation of sinus)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Chronic graft versus host disease in skin (damage by immune cells to skin after grafting)
Neoplasm progression (growth of tumour)
Pneumonia

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal impairment (severely reduced kidney function)

50-59:

Blood bilirubin increased
Blood creatinine increased
Platelet count decreased
Pneumonia adenoviral (viral pneumonia caused by an adenovirus)
Cytomegalovirus infection
Hepatic failure (liver failure)
Systemic candida (whole body fungal infection)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Venoocclusive liver disease (small veins in the liver are obstructed)
Abdominal pain

60+:

Aplasia (defective development or congenital absence of an organ or tissue)
Coma (state of unconsciousness lasting more than six hours)
Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
Coombs positive haemolytic anaemia
Cytomegalovirus infection
Sepsis (a severe blood infection that can lead to organ failure and death)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Thrombocytopenia (decrease of platelets in blood)
Anuria (failure of the kidneys to produce urine)
Eosinophilia (eosinophil count in the peripheral blood exceeds)

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 10 people, 22.22%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 20.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 13.33%
Infection: 5 people, 11.11%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 11.11%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 8.89%
Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 6.67%
Pneumonia Staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus): 3 people, 6.67%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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