Cymbalta and Dipyrone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Dipyrone (metamizole). Common drug interactions include tricuspid valve disease among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Dipyrone. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

What is Dipyrone?

Dipyrone has active ingredients of metamizole. eHealthMe is studying from 1,876 Dipyrone users. Check the latest studies of Dipyrone.

On Aug, 13, 2026

21 people who take Cymbalta and Dipyrone together, and have interactions are studied.

Cymbalta and Dipyrone drug interactions.

What are the common drug interactions of Cymbalta and Dipyrone, by gender? *:

female:

Tricuspid valve disease (disease of heart valve)
Vision blurred
Visual impairment
Vomiting
White blood cell count increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug dependence
Drug ineffective
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)

male:

Blood glucose increased
Coma (state of unconsciousness lasting more than six hours)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Foot fracture
Fracture
Glycosylated haemoglobin increased
Hepatic steatosis (fatty liver disease)
Inspiratory capacity decreased
Loss of consciousness
Malignant neoplasm of pleura (cancer tumour of lung covering)

What are the common drug interactions of Cymbalta and Dipyrone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pancreatitis (inflammation of pancreas)
Activated partial thromboplastin time shortened
Alanine aminotransferase increased
Arthropathy
C-reactive protein increased
Daydreaming
Drug dependence
Drug ineffective
Fatigue (feeling of tiredness)
Gait disturbance

30-39:

n/a

40-49:

Coma (state of unconsciousness lasting more than six hours)
Suicide attempt
Inspiratory capacity decreased
Loss of consciousness
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Diarrhoea
Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Electrocardiogram qt prolonged
Hypertensive crisis
International normalised ratio decreased
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Nausea (feeling of having an urge to vomit)

60+:

Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Back pain
Behavioural and psychiatric symptoms of dementia
Blood creatine increased
Blood creatine phosphokinase increased
Blood glucose increased
Blood triglycerides increased
Cardiac arrest
Cardiac failure

What are the existing conditions these people have? *

Pain: 5 people, 23.81%
Muscle Spasms (muscle contraction): 3 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 14.29%
Diabetes: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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