Cymbalta and Methylprednisolone acetate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Methylprednisolone acetate (methylprednisolone acetate). Common drug interactions include injection site pain among females and abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Methylprednisolone acetate. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Methylprednisolone acetate?

Methylprednisolone acetate has active ingredients of methylprednisolone acetate. eHealthMe is studying from 2,816 Methylprednisolone acetate users. Check the latest studies of Methylprednisolone acetate.

On Jul, 05, 2026

75 people who take Cymbalta and Methylprednisolone acetate together, and have interactions are studied.

Cymbalta and Methylprednisolone acetate drug interactions.

What are the common drug interactions of Cymbalta and Methylprednisolone Acetate, by gender? *:

female:

Injection site pain
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Iron deficiency anaemia
Pain
Fall
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Urticaria (rash of round, red welts on the skin that itch intensely)
Cough

male:

Abscess (pus)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Sudden death
Ankle fracture
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Compression fracture (fracture due to pressure caused by injury)
Emotional distress
Fracture
Infective myositis (infection of skeletal muscle)
Pain

What are the common drug interactions of Cymbalta and Methylprednisolone Acetate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Injection site mass
Erythema (redness of the skin)
Injection site haemorrhage (bleeding from injection site)
Injection site rash

40-49:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Asthma
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Device occlusion
Dizziness
Ear congestion
Fall
Fatigue (feeling of tiredness)

50-59:

Cough
Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful)
Diarrhoea
Dry eye (lack of adequate tears)
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Electric shock
Fall
Glomerular filtration rate increased

60+:

Acute sinusitis
Fall
Gastroenteritis (inflammation of stomach and intestine)
Injection site pain
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Iron deficiency anaemia
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain in extremity
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 23 people, 30.67%
High Blood Pressure: 15 people, 20.00%
Immunodeficiency Common Variable: 10 people, 13.33%
Asthma: 9 people, 12.00%
Nausea And Vomiting: 8 people, 10.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.67%
Diabetes: 8 people, 10.67%
Stress And Anxiety: 8 people, 10.67%
Blood Pressure Abnormal: 7 people, 9.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 9.33%

* Approximation only. Some reports may have incomplete information.

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