Cymbalta and Nardil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Nardil (phenelzine sulfate). Common drug interactions include gait disturbance among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Nardil. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Nardil?

Nardil has active ingredients of phenelzine sulfate. It is often used in depression. eHealthMe is studying from 2,327 Nardil users. Check the latest studies of Nardil.

On Jul, 17, 2026

29 people who take Cymbalta and Nardil together, and have interactions are studied.

What are the common drug interactions of Cymbalta and Nardil, by gender? *:

female:

Gait disturbance
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gingival bleeding (bleeding gums)
Glaucoma (increased fluid pressure in the eye with vision loss)
Glossodynia (a burning or painful sensation in the tongue)
Groin pain
Haematochezia (passage of stools containing blood)
Haematuria (presence of blood in urine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

male:

Blood cholesterol increased
Drug ineffective
Glycosuria (excretion of glucose into the urine)
Hyperglycaemia (high blood sugar)
Speech disorder
Type 2 diabetes mellitus
Weight increased
Blood triglycerides increased
Cerebral disorder (brain disease)
Dependence

What are the common drug interactions of Cymbalta and Nardil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Panic attack
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Vomiting

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Mania (a state of abnormally elevated or irritable mood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Rash generalised (rash on most of body parts)

40-49:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hip fracture
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperkeratosis (thickening of the outer layer of the skin)
Hyperlipidaemia (presence of excess lipids in the blood)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypoacusis (loss of hearing)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoglobulinaemia (deficiency of globulin in the bloodstream)

50-59:

Coma (state of unconsciousness lasting more than six hours)
Pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Restless legs syndrome (a powerful urge to move your legs)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Stomach discomfort (pain in abdomen)

60+:

Drug ineffective
Oedema peripheral (superficial swelling)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug hypersensitivity
Fall
Glycosuria (excretion of glucose into the urine)
Hyperglycaemia (high blood sugar)
Joint swelling
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the existing conditions these people have? *

Stress And Anxiety: 11 people, 37.93%
Sleep Disorder: 8 people, 27.59%
Insomnia (sleeplessness): 3 people, 10.34%
Bipolar Disorder (mood disorder): 3 people, 10.34%
Precancerous Cells Present: 2 people, 6.90%
Post-Traumatic Stress Disorder: 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and Nardil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously