Cytomel and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytomel (liothyronine sodium) and Phenergan (promethazine hydrochloride). Common drug interactions include dizziness among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Cytomel and Phenergan. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Cytomel?

Cytomel has active ingredients of liothyronine sodium. It is often used in hypothyroidism. eHealthMe is studying from 7,595 Cytomel users. Check the latest studies of Cytomel.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Aug, 08, 2026

48 people who take Cytomel and Phenergan together, and have interactions are studied.

Cytomel and Phenergan drug interactions.

What are the common drug interactions of Cytomel and Phenergan, by gender? *:

female:

Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Headache (pain in head)
Muscle spasms (muscle contraction)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Palpitations (feelings or sensations that your heart is pounding or racing)
Back pain
Emotional distress
Pain in extremity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Peripheral swelling
Rash macular (small, flat red spots)
Rash pruritic (redness with itching)

What are the common drug interactions of Cytomel and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Asthenia (weakness)
Dizziness
Emotional distress
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)

40-49:

Suicidal ideation
Suicide attempt
Upper limb fracture
Application site burn
Application site discolouration
Application site discomfort
Application site erythema (redness of the skin at application site)
Application site irritation
Application site pain
Application site papules (solid elevation of skin with no visible fluid at application site)

50-59:

Myalgia (muscle pain)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neck injury
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Obsessive rumination (thinking and worry or rumination is an inability to gain control over recurrent, distressing thoughts, images)
Oedema (fluid collection in tissue)
Overweight
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Abdominal discomfort
Abdominal pain
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Full blood count decreased
Influenza like illness
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)

What are the existing conditions these people have? *

Pain: 13 people, 27.08%
Depression: 12 people, 25.00%
Migraine (headache): 9 people, 18.75%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 16.67%
Stress And Anxiety: 6 people, 12.50%
Hypersensitivity: 6 people, 12.50%
Iron Deficiency Anaemia: 4 people, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.33%
Drowsiness: 4 people, 8.33%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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