Cytotec and Buscopan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytotec (misoprostol) and Buscopan (hyoscine butylbromide). Common drug interactions include polyhydramnios among females and foetal exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Cytotec and Buscopan. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

30 people who take Cytotec and Buscopan together, and have interactions are studied.

What are the common drug interactions of Cytotec and Buscopan, by gender? *:

female:

Polyhydramnios (excess of amniotic fluid in the amniotic sac)
Compression fracture (fracture due to pressure caused by injury)
Haemochromatosis (body to absorb more iron than usual from food)
Influenza like illness
Meconium in amniotic fluid
Neck pain
Spinal compression fracture (fracture due to spinal compression on bone)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased

male:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Respiratory disorder neonatal (disease of respiratory organs in a month old baby)
Constipation
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Gastrointestinal perforation (hole in the digestive tract)
Neutropenia (an abnormally low number of neutrophils)
Umbilical cord around neck
Anaemia (lack of blood)
Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)

What are the common drug interactions of Cytotec and Buscopan, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Respiratory disorder neonatal (disease of respiratory organs in a month old baby)
Dysphagia (a condition in which swallowing is difficult or painful)
Hypertelorism of orbit (abnormally increased distance between two organs or bodily parts, usually referring to an increased distance between the orbits (eyes)--orbital hypertelorism)
Hypotonia neonatal (low muscle tone in neonatal)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Trismus (reduced opening of the jaws)
Visual impairment
Bradycardia neonatal (sinus rhythm with a heart rate below the normal limit in newborn)
Umbilical cord around neck

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Meconium in amniotic fluid

40-49:

Polyhydramnios (excess of amniotic fluid in the amniotic sac)
Influenza like illness
Induced labour (prematurely stimulating childbirth in a woman)
Meconium in amniotic fluid
Premature rupture of membranes

50-59:

n/a

60+:

Cholecystitis (infection of gallbladder)
Compression fracture (fracture due to pressure caused by injury)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood creatinine increased
Blood urea increased
Chest pain
Decreased appetite

What are the existing conditions these people have? *

Labor Induction: 23 people, 76.67%
Depression: 21 people, 70.00%
Labor Pain: 20 people, 66.67%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 10 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.67%
Pain: 2 people, 6.67%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 6.67%
Morning Sickness (sickness in morning during pregnancy): 2 people, 6.67%
Iron Deficiency: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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