Cytotec and Climara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytotec (misoprostol) and Climara (estradiol). Common drug interactions include bronchitis among females.

The phase IV clinical study analyzes what interactions people have when they take Cytotec and Climara. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.



On Aug, 01, 2026

15 people who take Cytotec and Climara together, and have interactions are studied.

Cytotec and Climara drug interactions.

What are the common drug interactions of Cytotec and Climara, by gender? *:

female:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Constipation
  3. Gastroenteritis (inflammation of stomach and intestine)
  4. Insomnia (sleeplessness)
  5. Night sweats (sweating in night)
  6. Pharyngitis (inflammation of the pharynx, causing a sore throat)
  7. Suicidal ideation
  8. Confusional state
  9. Headache (pain in head)
  10. Nightmare (unpleasant dream)

male:

n/a

What are the common drug interactions of Cytotec and Climara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Self mutilation
  2. Viral upper respiratory tract infection
  3. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  4. Blood thyroid stimulating hormone increased
  5. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  6. Chest pain
  7. Constipation
  8. Depression
  9. Drug dependence
  10. Drug ineffective

50-59:

  1. Dry mouth
  2. Euphoric mood (excessively happy but may become angry or irritable)
  3. Extrasystoles
  4. Headache (pain in head)
  5. Insomnia (sleeplessness)
  6. Mitral valve incompetence (inefficient heart valve)
  7. Palpitations (feelings or sensations that your heart is pounding or racing)
  8. Tricuspid valve incompetence (inefficient heart valve)
  9. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  10. Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)

60+:

  1. Abdominal pain
  2. Constipation
  3. Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
  2. Pancreatic Carcinoma (pancreatic cancer): 1 person, 6.67%
  3. Pain: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Cytotec and Climara?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cytotec and Climara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cytotec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Climara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cytotec and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Climara and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on misoprostol and estradiol (the active ingredients of Cytotec and Climara, respectively), and Cytotec and Climara (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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