Cytoxan and Nitrostat drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Cytoxan (cyclophosphamide) and Nitrostat (nitroglycerin). Common drug interactions include white blood cell count decreased among females and anaemia among males.
The phase IV clinical study analyzes what interactions people have when they take Cytoxan and Nitrostat. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.
What is Cytoxan?
Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.
What is Nitrostat?
Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
31 people who take Cytoxan and Nitrostat together, and have interactions are studied.

What are the common drug interactions of Cytoxan and Nitrostat, by gender? *:
female:
- White blood cell count decreased
- Abdominal pain lower
- B-lymphocyte count decreased
- C-reactive protein increased
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Dizziness
- Drug ineffective
- Dysphagia (a condition in which swallowing is difficult or painful)
- Eye pain
- Facial bones fracture (bone fracture of face)
male:
- Anaemia (lack of blood)
- Asthenia (weakness)
- Back pain
- Balance disorder
- Blindness transient (sudden loss of vision)
- Blood immunoglobulin a increased
- Bone fistula
- Bone pain
- Breast pain
- Breast swelling
What are the common drug interactions of Cytoxan and Nitrostat, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Anaemia (lack of blood)
- Anxiety
- Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
- Aphasia (damage to the parts of the brain that control language)
- Asbestosis (chronic lung disease caused by scarring of lung tissue, which stems from prolonged exposure to asbestos)
- Asthenia (weakness)
- Back pain
- Balance disorder
- Blindness cortical
- Blindness transient (sudden loss of vision)
60+:
- Alopecia (absence of hair from areas of the body)
- Anxiety
- Asthenia (weakness)
- Herpes zoster
- Oedema peripheral (superficial swelling)
- Affective disorder (mental disorder)
- Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
- Aphasia (damage to the parts of the brain that control language)
- Asbestosis (chronic lung disease caused by scarring of lung tissue, which stems from prolonged exposure to asbestos)
- Back pain
What are the existing conditions these people have? *
- Breast Cancer Female: 9 people, 29.03%
- Pain: 3 people, 9.68%
- Vasculitis (inflammation of a blood vessel or blood vessels): 2 people, 6.45%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.45%
- Optic Neuritis (optic nerve inflammation): 2 people, 6.45%
- Hypersensitivity: 2 people, 6.45%
- High Blood Pressure: 2 people, 6.45%
- Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 2 people, 6.45%
- Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 6.45%
- Breast Cancer Metastatic: 2 people, 6.45%
* Approximation only. Some reports may have incomplete information.
Do you take Cytoxan and Nitrostat?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Cytoxan and Nitrostat:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Cytoxan:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Nitrostat:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cytoxan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Nitrostat and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
How the study uses the data?
The study uses data from the FDA. It is based on cyclophosphamide and nitroglycerin (the active ingredients of Cytoxan and Nitrostat, respectively), and Cytoxan and Nitrostat (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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