Cytoxan and Roxicodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cytoxan (cyclophosphamide) and Roxicodone (oxycodone hydrochloride). Common drug interactions include anxiety among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Cytoxan and Roxicodone. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

What is Roxicodone?

Roxicodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 20,099 Roxicodone users. Check the latest studies of Roxicodone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

73 people who take Cytoxan and Roxicodone together, and have interactions are studied.

Cytoxan and Roxicodone drug interactions.

What are the common drug interactions of Cytoxan and Roxicodone, by gender? *:

female:

Anxiety
Bone disorder
Injury
Osteomyelitis (infection of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Osteonecrosis of jaw (death of bone of jaw)
Arthralgia (joint pain)
Back pain
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Blood glucose increased
Blood potassium decreased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Weight decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Hypoxia (low oxygen in tissues)
Headache (pain in head)
Pancreatitis (inflammation of pancreas)

What are the common drug interactions of Cytoxan and Roxicodone, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

n/a

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)

30-39:

Alopecia (absence of hair from areas of the body)
Malignant neoplasm progression (cancer tumour came back)
Neoplasm progression (growth of tumour)

40-49:

Actinomycosis (infection that causes sores, or abscesses)
Anaemia (lack of blood)
Anxiety
Bone disorder
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebral atrophy (decrement in size of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation

50-59:

Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Oropharyngeal pain
Syncope (loss of consciousness with an inability to maintain postural tone)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dizziness
Epididymitis (pain in the scrotum or testicle)
Eye irritation
Eye swelling
Fatigue (feeling of tiredness)

60+:

Anaemia (lack of blood)
Bone disorder
Spinal osteoarthritis (joint cartilage loss in spine)
Back pain
Osteonecrosis of jaw (death of bone of jaw)
Arthralgia (joint pain)
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysphonia (speech disorder attributable to a disorder of phonation)
Facial pain

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 27 people, 36.99%
High Blood Pressure: 24 people, 32.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 21 people, 28.77%
Stress And Anxiety: 19 people, 26.03%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 19 people, 26.03%
Metastases To Bone (cancer spreads to bone): 18 people, 24.66%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 18 people, 24.66%
Muscle Spasms (muscle contraction): 14 people, 19.18%
Insomnia (sleeplessness): 11 people, 15.07%
Nausea (feeling of having an urge to vomit): 9 people, 12.33%

* Approximation only. Some reports may have incomplete information.

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