Daptomycin and Doxycycline hyclate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daptomycin (daptomycin) and Doxycycline hyclate (doxycycline hyclate). Common drug interactions include pyrexia among females and staphylococcal infection among males.

The phase IV clinical study analyzes what interactions people have when they take Daptomycin and Doxycycline hyclate. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

On Aug, 12, 2026

39 people who take Daptomycin and Doxycycline hyclate together, and have interactions are studied.

Daptomycin and Doxycycline hyclate drug interactions.

What are the common drug interactions of Daptomycin and Doxycycline Hyclate, by gender? *:

female:

Pyrexia (fever)
Back pain
Blood creatinine increased
Intervertebral discitis (infection in the intervertebral disc space)
Nausea (feeling of having an urge to vomit)
Osteonecrosis (death of bone)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Arteriosclerosis (thickening and hardening of arteries)
Asymptomatic bacteriuria (the presence of bacteria in urine not due to contamination from urine sample collection)
Atrophy (wasting away of a part of the body)

male:

Staphylococcal infection (an infection with staphylococcus bacteria)
General physical health deterioration (weak health status)
Gamma-glutamyltransferase increased
Insomnia (sleeplessness)
Interstitial lung disease
Muscle spasms (muscle contraction)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Osteomyelitis (infection of bone)
Renal failure (kidney dysfunction)
Skin ulcer

What are the common drug interactions of Daptomycin and Doxycycline Hyclate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug hypersensitivity
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Skin lesion
Drug ineffective
Blood creatine phosphokinase increased
Erythema (redness of the skin)
Pain of skin
Abscess (pus)

30-39:

Drug ineffective
Drug resistance (reduction in effectiveness of a drug)

40-49:

Back pain
Blood creatinine increased
Intervertebral discitis (infection in the intervertebral disc space)
Osteonecrosis (death of bone)
Arteriosclerosis (thickening and hardening of arteries)
Asymptomatic bacteriuria (the presence of bacteria in urine not due to contamination from urine sample collection)
Atrophy (wasting away of a part of the body)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Inflammatory marker increased
Pyrexia (fever)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Gamma-glutamyltransferase increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Osteomyelitis (infection of bone)
Skin ulcer

60+:

Small intestinal obstruction (blockage in small intestine)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Cauda equina syndrome (affecting the bundle of nerve roots)
Drug hypersensitivity
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Eosinophilic pneumonia (eosinophil accumulates in the lung)
Interstitial lung disease

What are the existing conditions these people have? *

Staphylococcal Infection (an infection with staphylococcus bacteria): 15 people, 38.46%
Pain: 14 people, 35.90%
Osteomyelitis (infection of bone): 4 people, 10.26%
Pneumonia: 3 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.69%
Paraspinal Abscess: 3 people, 7.69%
Intervertebral Discitis (infection in the intervertebral disc space): 3 people, 7.69%
Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 7.69%
Burkholderia Cepacia Complex Infection (complex infection by group of bacteria burkholderia cepacia -resistant to common antibiotics): 3 people, 7.69%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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