Daptomycin and Solu-medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daptomycin (daptomycin) and Solu-medrol (methylprednisolone sodium succinate). Common drug interactions include paraesthesia among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Daptomycin and Solu-medrol. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Solu-medrol?

Solu-medrol has active ingredients of methylprednisolone sodium succinate. It is often used in multiple sclerosis. eHealthMe is studying from 39,410 Solu-medrol users. Check the latest studies of Solu-medrol.

On Jul, 31, 2026

54 people who take Daptomycin and Solu-medrol together, and have interactions are studied.

Daptomycin and Solu-medrol drug interactions.

What are the common drug interactions of Daptomycin and Solu-Medrol, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Chills (felling of cold)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Septic shock (shock due to blood infection)
Thrombocytopenia (decrease of platelets in blood)
Device related infection
Fatigue (feeling of tiredness)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Immunosuppression

male:

Vomiting
Pneumonia
Skin infection
Abdominal pain
Cachexia (loss of weight)
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deformity (disfigurement)

What are the common drug interactions of Daptomycin and Solu-Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Blood bilirubin increased
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Vomiting
White blood cell count decreased

20-29:

Axonal neuropathy (dysfunction of axon nerves)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Chest pain
Headache (pain in head)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
Infectious pleural effusion (infectious fluid in the lung)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Myelomalacia (softening and damage of the spinal cord due to some injury like compression by disc extrusion)

30-39:

Device related infection
Acute respiratory distress syndrome
Acute respiratory failure
Ammonia increased
Cardiac arrest
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hyperglycaemia (high blood sugar)

40-49:

Chills (felling of cold)
Blood pressure fluctuation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Enterocolitis haemorrhagic (bleeding and inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Hypotension (abnormally low blood pressure)
Pulmonary embolism (blockage of the main artery of the lung)
Rectal haemorrhage (bleeding from anus)
Septic shock (shock due to blood infection)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Vomiting
Chronic kidney disease
Neutropenia (an abnormally low number of neutrophils)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Abdominal distension
Abdominal hernia
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain

60+:

Anaemia (lack of blood)
Pneumonia
Cachexia (loss of weight)
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deformity (disfigurement)
Escherichia sepsis (bacterial infection by escherichia coli)
Failure to thrive (inadequate weight gain and physical growth in children)

What are the existing conditions these people have? *

Stress And Anxiety: 15 people, 27.78%
Nausea (feeling of having an urge to vomit): 14 people, 25.93%
Pain: 14 people, 25.93%
Constipation: 10 people, 18.52%
Hypersensitivity: 7 people, 12.96%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 12.96%
Hypokalemia (low potassium): 7 people, 12.96%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 6 people, 11.11%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 6 people, 11.11%
Headache (pain in head): 6 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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