Daraprim and Zerit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daraprim (pyrimethamine) and Zerit (stavudine). Common drug interactions include anaemia among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Daraprim and Zerit. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Daraprim?

Daraprim has active ingredients of pyrimethamine. eHealthMe is studying from 788 Daraprim users. Check the latest studies of Daraprim.

What is Zerit?

Zerit has active ingredients of stavudine. eHealthMe is studying from 9,912 Zerit users. Check the latest studies of Zerit.

On Aug, 02, 2026

22 people who take Daraprim and Zerit together, and have interactions are studied.

What are the common drug interactions of Daraprim and Zerit, by gender? *:

female:

Anaemia (lack of blood)
Central nervous system lymphoma (cancer of central nervous system forms in lymph tissue)
Platelet count decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Depressed level of consciousness
Abdominal distension
Abdominal pain
Blood creatine phosphokinase increased
Blood lactate dehydrogenase increased
C-reactive protein increased

male:

Renal impairment (severely reduced kidney function)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Blood alkaline phosphatase nos increased
Blood creatinine increased
C-reactive protein increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Death
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

What are the common drug interactions of Daraprim and Zerit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Thrombocytopenia (decrease of platelets in blood)

40-49:

Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Haemoglobin decreased
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hepatic failure (liver failure)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Blood alkaline phosphatase nos increased
Blood creatinine increased

50-59:

n/a

60+:

Anaemia (lack of blood)
Central nervous system lymphoma (cancer of central nervous system forms in lymph tissue)
Platelet count decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Depressed level of consciousness

What are the existing conditions these people have? *

Hiv Infection: 5 people, 22.73%
Mycobacterium Avium Complex Infection: 4 people, 18.18%
Cytomegalovirus Enterocolitis (virus infection of intestine and colon): 4 people, 18.18%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 9.09%
Cerebral Toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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