Darvon and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Darvon (propoxyphene hydrochloride) and Oxycontin (oxycodone hydrochloride). Common drug interactions include tooth loss among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Darvon and Oxycontin. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Darvon?

Darvon has active ingredients of propoxyphene hydrochloride. It is often used in pain. eHealthMe is studying from 2,762 Darvon users. Check the latest studies of Darvon.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

On Jun, 13, 2026

54 people who take Darvon and Oxycontin together, and have interactions are studied.

What are the common drug interactions of Darvon and Oxycontin, by gender? *:

female:

Tooth loss
Tremor (trembling or shaking movements in one or more parts of your body)
Ulcer
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Adjustment disorder with depressed mood
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Catatonia (unresponsive to external stimuli)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chills (felling of cold)

male:

Drug dependence
Overdose
Drug abuser
Euphoric mood (excessively happy but may become angry or irritable)
Hepatic failure (liver failure)
Nausea (feeling of having an urge to vomit)
Suicidal behaviour
Suicide attempt
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Darvon and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug abuser
Drug dependence

20-29:

n/a

30-39:

n/a

40-49:

Blood creatine phosphokinase increased
Blood pressure decreased
Body temperature increased
Coma (state of unconsciousness lasting more than six hours)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Electrocardiogram qt prolonged
Heart rate decreased
Lethargy (tiredness)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Multiple drug overdose

50-59:

Drug dependence
Muscle spasms (muscle contraction)
Arthralgia (joint pain)
Drug ineffective
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc degeneration (spinal disc degeneration)
Lumbar radiculopathy (radicular pain in the low back and legs)
Post laminectomy syndrome
Sleep disorder
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

60+:

Drug hypersensitivity
Back injury
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chronic kidney disease
Drug dependence
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperlipidaemia (presence of excess lipids in the blood)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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