Delsym and Benzonatate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Delsym (dextromethorphan polistirex) and Benzonatate (benzonatate). Common drug interactions include muscular weakness among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Delsym and Benzonatate. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Delsym?

Delsym has active ingredients of dextromethorphan polistirex. It is often used in cough. eHealthMe is studying from 5,033 Delsym users. Check the latest studies of Delsym.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

57 people who take Delsym and Benzonatate together, and have interactions are studied.

Delsym and Benzonatate drug interactions.

What are the common drug interactions of Delsym and Benzonatate, by gender? *:

female:

Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Pain
Renal disorder (kidney disease)
Rib fracture
Scab (a hard coating on the skin formed during the wound healing)
Staring (a prolonged gaze or fixed look)
Weight decreased
Acne pustular (acne-white centre surrounded by red skin-skin disease)
Arthralgia (joint pain)

male:

Death
Electrocardiogram qt prolonged
Anxiety
Chronic kidney disease
Dizziness
Emotional distress
Gastrointestinal hypomotility (less activity of the intestinal tract)
Pain
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Small intestinal obstruction (blockage in small intestine)

What are the common drug interactions of Delsym and Benzonatate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Haematochezia (passage of stools containing blood)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Rash
Vomiting

10-19:

n/a

20-29:

n/a

30-39:

Dizziness
Hyperventilation
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

Hospitalisation
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Infusion site swelling
Infusion site warmth
Insomnia (sleeplessness)
Malignant neoplasm progression (cancer tumour came back)
Pyrexia (fever)
Skin discolouration (change of skin colour)
Skin exfoliation (removal of the oldest dead skin cells)

50-59:

Pneumonia
Fatigue (feeling of tiredness)
Urinary tract infection
Infection
Asthma
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Contusion (a type of hematoma of tissue in which capillaries)
Electrocardiogram qt prolonged
Feeling hot
Impaired gastric emptying

60+:

Death
Fall
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Joint stiffness
Limb injury
Lung transplant
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Pruritus generalised (generalized itching)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 17.54%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 15.79%
High Blood Cholesterol: 9 people, 15.79%
Constipation: 8 people, 14.04%
Pain: 7 people, 12.28%
Multiple Myeloma (cancer of the plasma cells): 7 people, 12.28%
Immunodeficiency Common Variable: 7 people, 12.28%
Asthma: 6 people, 10.53%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 6 people, 10.53%
Cardiac Disorder: 6 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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