Demadex and Apresoline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Demadex (torsemide) and Apresoline (hydralazine hydrochloride). Common drug interactions include hypocalcaemia among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Demadex and Apresoline. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Demadex?

Demadex has active ingredients of torsemide. It is often used in heart failure. eHealthMe is studying from 5,358 Demadex users. Check the latest studies of Demadex.

What is Apresoline?

Apresoline has active ingredients of hydralazine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,475 Apresoline users. Check the latest studies of Apresoline.

On Jul, 25, 2026

72 people who take Demadex and Apresoline together, and have interactions are studied.

Demadex and Apresoline drug interactions.

What are the common drug interactions of Demadex and Apresoline, by gender? *:

female:

Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Urinary tract infection
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Anxiety
Injury
Pain
Pain in jaw
Abdominal pain upper
Disability
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

male:

Cardiac failure congestive
Nausea (feeling of having an urge to vomit)
Balance disorder
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Insomnia (sleeplessness)
Pain
Cerebral haemorrhage (bleeding within the brain)
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Anoxic encephalopathy (brain damage due to lack of oxygen)

What are the common drug interactions of Demadex and Apresoline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood glucose increased
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Pitting oedema (skin discoloration)

40-49:

Cardiac failure congestive
Cardiac failure acute
Chest pain
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
General physical health deterioration (weak health status)
Hypoxia (low oxygen in tissues)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Disability
Dyspnoea (difficult or laboured respiration)
Haematoma (collection of blood outside the blood vessels)
Haematuria (presence of blood in urine)
International normalised ratio increased
Pancreatitis chronic (chronic inflammation of pancreas)
Rectal haemorrhage (bleeding from anus)
Thrombocytopenia (decrease of platelets in blood)
Viral upper respiratory tract infection

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Anxiety
Dizziness
Injury
Pain in jaw
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Decreased appetite

What are the existing conditions these people have? *

Diabetes: 12 people, 16.67%
Constipation: 11 people, 15.28%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 11 people, 15.28%
Pain: 11 people, 15.28%
Type 2 Diabetes: 10 people, 13.89%
Anaemia (lack of blood): 8 people, 11.11%
Chest Pain: 7 people, 9.72%
Oedema Peripheral (superficial swelling): 7 people, 9.72%
Joint Pain: 6 people, 8.33%
Dizziness: 6 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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