Depakene and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakene (valproic acid) and Colace (docusate ). Common drug interactions include confusional state among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Depakene and Colace. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

On Jul, 25, 2026

33 people who take Depakene and Colace together, and have interactions are studied.

What are the common drug interactions of Depakene and Colace, by gender? *:

female:

Confusional state
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Drug level decreased
Gait disturbance
Pain
Poor venous access
Somnolence (a state of near-sleep, a strong desire for sleep)
Arrhythmia (irregular heartbeat)
Blood albumin decreased
Blood potassium decreased

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Neutropenia (an abnormally low number of neutrophils)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depressed mood
Disturbance in attention
Dizziness
General physical health deterioration (weak health status)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperglycaemia (high blood sugar)

What are the common drug interactions of Depakene and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abdominal discomfort
Diarrhoea
Nausea (feeling of having an urge to vomit)
Adverse drug reaction
Hypophagia (reduced food intake)

20-29:

Confusional state
Lethargy (tiredness)
Muscle rigidity (muscle stiffness)
Overdose
Speech disorder

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Antisocial personality disorder
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depressed mood
Disturbance in attention
Dizziness
General physical health deterioration (weak health status)

40-49:

Asthenia (weakness)
Blindness transient (sudden loss of vision)
Bone disorder
Cardiac disorder
Dizziness
Ejaculation disorder
Fall
Finger deformity (a deformed position of the finger)
Hypertension (high blood pressure)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

Blood pressure decreased
Calculus bladder (bladder stone)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Fall
Hyperadrenalism (excessive levels of adrenal hormones in the body)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Oxygen saturation decreased

60+:

Fall
Pain
Poor venous access
Arrhythmia (irregular heartbeat)
Blood albumin decreased
Bradycardia (abnormally slow heart action)
Cardiac failure
Electrocardiogram abnormal
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Pain: 11 people, 33.33%
Fever: 9 people, 27.27%
Nausea (feeling of having an urge to vomit): 9 people, 27.27%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 24.24%
Headache (pain in head): 8 people, 24.24%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 7 people, 21.21%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 18.18%
Insomnia (sleeplessness): 6 people, 18.18%
Depression: 4 people, 12.12%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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