Depakene and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakene (valproic acid) and Prograf (tacrolimus). Common drug interactions include gastrointestinal disorder among females and cytomegalovirus viraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Depakene and Prograf. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 15, 2026

56 people who take Depakene and Prograf together, and have interactions are studied.

What are the common drug interactions of Depakene and Prograf, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Immunosuppressant drug level increased
Lymphadenopathy (disease or enlargement of lymph nodes)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anogenital warts
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Immunosuppressant drug level decreased
Stomatitis (inflammation of mucous membrane of mouth)

male:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Urine output decreased
Coronary artery stenosis (narrowing of coronary artery)
Transitional cell carcinoma (cancer tumour inner most layer of urinary system)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Febrile neutropenia (fever with reduced white blood cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Depakene and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dyskinesia (abnormality or impairment of voluntary movement)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Eye discharge
Gastrointestinal hypermotility (over activity of the intestinal tract)
Hyperkalaemia (damage to or disease of the kidney)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

10-19:

Post transplant lymphoproliferative disorder

20-29:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Systemic candida (whole body fungal infection)
Bacterial infection
Encephalitis viral (inflammation of the brain due to viral infection)

30-39:

Coronary artery stenosis (narrowing of coronary artery)
Transitional cell carcinoma (cancer tumour inner most layer of urinary system)
Bone marrow failure
Granulocytopenia (lack of granulocyte)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Staphylococcal infection (an infection with staphylococcus bacteria)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

40-49:

Glaucoma (increased fluid pressure in the eye with vision loss)
Hypotension (abnormally low blood pressure)
Lymphocyte count decreased
Nausea (feeling of having an urge to vomit)
Vomiting
Blood creatine phosphokinase increased
Contusion (a type of hematoma of tissue in which capillaries)
Endometrial hyperplasia (enlargement of uterus wall)
Fall
Genital haemorrhage (bleeding from genital)

50-59:

Herpes zoster
Cardiac failure
Constipation
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Engraft failure
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

60+:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Muscle contractions involuntary (uncontrolled muscle contraction)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Renal failure acute (rapid kidney dysfunction)
Respiratory distress (difficulty in breathing)
Anaemia (lack of blood)
Blood lactate dehydrogenase increased
Blood sodium decreased
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 13 people, 23.21%
Hepatic Function Abnormal: 8 people, 14.29%
Pain: 7 people, 12.50%
High Blood Pressure: 6 people, 10.71%
Pyelonephritis Fungal (inflammation of kidney caused by fungal infection): 6 people, 10.71%
Pruritus Genital (uneasy irritation of the skin of the vagina and the surrounding area): 6 people, 10.71%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 6 people, 10.71%
Infection: 6 people, 10.71%
Conjunctivitis (pink eye): 6 people, 10.71%
Cytomegalovirus Infection: 6 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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