Depakene and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakene (valproic acid) and Tylenol (acetaminophen). Common drug interactions include dyspnoea among females and loss of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Depakene and Tylenol. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

On Aug, 05, 2026

77 people who take Depakene and Tylenol together, and have interactions are studied.

What are the common drug interactions of Depakene and Tylenol, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fall
Hypovolaemia (a decreased volume of circulating blood in the body)
Lethargy (tiredness)
Menopause (end of monthly cycles in women)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Urinary retention (the inability to completely or partially empty the bladder)
Vomiting
Asthenia (weakness)

male:

Loss of consciousness
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Fall
Neutropenia (an abnormally low number of neutrophils)
Renal failure (kidney dysfunction)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Antisocial personality disorder
Arthralgia (joint pain)
Asthenia (weakness)
Back pain

What are the common drug interactions of Depakene and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Muscular weakness (muscle weakness)
Pneumonia
Anticonvulsant drug level below therapeutic
Blood glucose increased
Cardiac arrest
Dehydration (dryness resulting from the removal of water)
Hypovolaemia (a decreased volume of circulating blood in the body)
Lethargy (tiredness)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Pneumonia
Abdominal discomfort
Diarrhoea
Nausea (feeling of having an urge to vomit)
Abdominal distension
Influenza
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection
Adverse drug reaction

20-29:

Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
Acute respiratory failure
Asthenia (weakness)
Drug ineffective
Dry eye (lack of adequate tears)
Dysphagia (a condition in which swallowing is difficult or painful)
Inflammation
Oral disorder (mouth disease)
Pigmentation disorder (disturbances of human skin colour)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Antisocial personality disorder
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depressed mood
Disturbance in attention

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bacterial test positive
Blindness
Blood creatine phosphokinase increased
Brain injury
Cardiac arrest
Cerebral artery occlusion (blockage of blood vessel of brain by fat or clot)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Conjunctivitis (pink eye)

50-59:

International normalised ratio increased
Blood potassium decreased
Blood pressure decreased
Calculus bladder (bladder stone)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Fall
Hyperadrenalism (excessive levels of adrenal hormones in the body)
Leukopenia (less number of white blood cells in blood)

60+:

Fall
Back pain
Abdominal pain upper
Adrenal mass
Agitation (state of anxiety or nervous excitement)
Cough
Dementia (madness)
Ear pain
Essential hypertension (primary hypertension)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Fever: 17 people, 22.08%
Headache (pain in head): 11 people, 14.29%
Constipation: 11 people, 14.29%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 10 people, 12.99%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 10 people, 12.99%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 11.69%
Nausea (feeling of having an urge to vomit): 8 people, 10.39%
Insomnia (sleeplessness): 8 people, 10.39%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 10.39%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 7 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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