Depakote er and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote er (divalproex sodium) and Actos (pioglitazone hydrochloride). Common drug interactions include deafness among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote er and Actos. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 09, 2026

32 people who take Depakote er and Actos together, and have interactions are studied.

Depakote er and Actos drug interactions.

What are the common drug interactions of Depakote Er and Actos, by gender? *:

female:

Deafness
Depressed mood
Depression
Diabetes mellitus inadequate control
Diplopia (double vision)
Drug ineffective
Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Coma hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatitis (inflammation of the liver)
Hepatitis c
Liver disorder (liver diseases)
Arthralgia (joint pain)

What are the common drug interactions of Depakote Er and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Obesity (having too much body fat)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic nephropathy (diabetic kidney disease)
Renal failure (kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Diabetes mellitus inadequate control
Neuropathy peripheral (surface nerve damage)
Blood cholesterol increased
Abdominal pain

40-49:

Oedema peripheral (superficial swelling)
Ophthalmoplegia (a paralysis or weakness of one or more of the muscles that control eye movement)
Osteoporosis (bones weak and more likely to break)
Pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Persecutory delusion
Petit mal epilepsy (absence seizure)
Phlebitis superficial (inflammation of the walls of a vein-superficial)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)

50-59:

Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Hepatic steatosis (fatty liver disease)
Insomnia (sleeplessness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pancreatitis acute (sudden inflammation of pancreas)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Anaemia (lack of blood)
Arthralgia (joint pain)
Blood cholesterol increased

60+:

Back pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Drug intolerance (drug sensitivity)
Ketoacidosis (high concentrations of ketone bodies in blood)

What are the existing conditions these people have? *

Depression: 7 people, 21.88%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 18.75%
Agitation (state of anxiety or nervous excitement): 6 people, 18.75%
Affective Disorder (mental disorder): 6 people, 18.75%
Type 2 Diabetes: 4 people, 12.50%
Sleep Disorder: 4 people, 12.50%
High Blood Pressure: 4 people, 12.50%
Pain: 3 people, 9.38%
Stress And Anxiety: 2 people, 6.25%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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