Depakote er and Tecfidera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote er (divalproex sodium) and Tecfidera (dimethyl fumarate). Common drug interactions include abdominal pain upper among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote er and Tecfidera. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

On Jul, 08, 2026

31 people who take Depakote er and Tecfidera together, and have interactions are studied.

Depakote er and Tecfidera drug interactions.

What are the common drug interactions of Depakote Er and Tecfidera, by gender? *:

female:

Abdominal pain upper
Pain
Headache (pain in head)
Balance disorder
Fall
Foot fracture
Nausea (feeling of having an urge to vomit)
Rib fracture
Drug ineffective
Fatigue (feeling of tiredness)

male:

Vomiting
Asthenia (weakness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Psychotic disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Death
Decreased appetite
Diarrhoea
Influenza like illness
Suicide attempt

What are the common drug interactions of Depakote Er and Tecfidera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus inadequate control
Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Completed suicide (act of taking one's own life)
Flushing (the warm, red condition of human skin)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Psychotic disorder
Kidney infection
Urinary tract infection

40-49:

Abdominal discomfort
Abdominal distension
Abdominal pain upper
Akinesia (loss of control of voluntary muscle movements)
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Fatigue (feeling of tiredness)
Frequent bowel movements
Gastrointestinal motility disorder (abnormal intestinal contractions)
Hot flush (sudden feelings of heat)

50-59:

Abdominal pain upper
Campylobacter gastroenteritis (infection of gastrointestinal system)
Choking sensation (feeling of obstruction in respiratory system)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dysphagia (a condition in which swallowing is difficult or painful)
Epistaxis (bleed from the nose)
Flushing (the warm, red condition of human skin)
Gastric disorder (disease of stomach)
Pruritus (severe itching of the skin)
Speech disorder

60+:

Fatigue (feeling of tiredness)
Headache (pain in head)
Lethargy (tiredness)
Vomiting

What are the existing conditions these people have? *

Headache (pain in head): 2 people, 6.45%
Gait Disturbance: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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