Depakote and Drisdol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote (divalproex sodium) and Drisdol (ergocalciferol). Common drug interactions include overweight among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote and Drisdol. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Drisdol?

Drisdol has active ingredients of ergocalciferol. It is often used in vitamin d. eHealthMe is studying from 1,741 Drisdol users. Check the latest studies of Drisdol.

On Aug, 08, 2026

33 people who take Depakote and Drisdol together, and have interactions are studied.

What are the common drug interactions of Depakote and Drisdol, by gender? *:

female:

Overweight
Pallor
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Thirst
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Back pain
Gait disturbance

male:

Nausea (feeling of having an urge to vomit)
Platelet count decreased
Blood calcium decreased
Blood creatine decreased
Blood glucose increased
Blood thyroid stimulating hormone increased
Body temperature decreased
Carbon dioxide increased
Confusional state
Depression

What are the common drug interactions of Depakote and Drisdol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Appetite disorder (abnormal eating habits)
Dysgeusia (disorder of the sense of taste)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Platelet count decreased
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Ageusia (loss of taste functions of the tongue)
Colitis (inflammation of colon)
Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anion gap decreased
Asthenia (weakness)
Balance disorder
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased

50-59:

Dizziness
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Pallor
Somnolence (a state of near-sleep, a strong desire for sleep)
Thirst
Blood pressure immeasurable
Bradycardia (abnormally slow heart action)
Cold sweat

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Fall
Haemorrhage intracranial (bleeding within the skull)
Insomnia (sleeplessness)
Loss of consciousness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Constipation: 13 people, 39.39%
Stress And Anxiety: 11 people, 33.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 24.24%
Depression: 8 people, 24.24%
Pain: 7 people, 21.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 21.21%
Nausea (feeling of having an urge to vomit): 6 people, 18.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 18.18%
Fever: 5 people, 15.15%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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