Depakote and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote (divalproex sodium) and Mesalamine (mesalamine). Common drug interactions include adrenal insufficiency among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote and Mesalamine. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

On Jul, 16, 2026

23 people who take Depakote and Mesalamine together, and have interactions are studied.

Depakote and Mesalamine drug interactions.

What are the common drug interactions of Depakote and Mesalamine, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Abdominal pain
Abdominal pain upper
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Chronic kidney disease
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Osteoporosis (bones weak and more likely to break)
Confusional state

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Diarrhoea
Dysstasia (difficulty in standing)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition)
Pneumonia
Repetitive speech
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

What are the common drug interactions of Depakote and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Gastroenteritis (inflammation of stomach and intestine)

20-29:

Abdominal pain
Abdominal pain upper
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

30-39:

Diarrhoea
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood lactic acid increased
Drug ineffective
Pain
Pneumonia
Vomiting

40-49:

Body temperature increased
Cd4 lymphocytes decreased
Confusional state
Dysarthria (speech disorder)
Gait disturbance
Insomnia (sleeplessness)
Loss of employment
Muscle rigidity (muscle stiffness)
Neoplasm malignant (cancer tumour)
Pain in extremity

50-59:

n/a

60+:

Dysstasia (difficulty in standing)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition)
Repetitive speech
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the existing conditions these people have? *

Pain: 9 people, 39.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 17.39%
Infection: 3 people, 13.04%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 13.04%
Mania (a state of abnormally elevated or irritable mood): 2 people, 8.70%
Inflammatory Bowel Disease: 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
Blood Pressure Abnormal: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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