Depakote and Multaq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote (divalproex sodium) and Multaq (dronedarone hydrochloride). Common drug interactions include drug hypersensitivity among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote and Multaq. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Multaq?

Multaq has active ingredients of dronedarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 11,053 Multaq users. Check the latest studies of Multaq.

On Jul, 07, 2026

17 people who take Depakote and Multaq together, and have interactions are studied.

What are the common drug interactions of Depakote and Multaq, by gender? *:

female:

Drug hypersensitivity
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Rectal haemorrhage (bleeding from anus)
Abnormal dreams
Chest pain
Granulocytopenia (lack of granulocyte)
Haemoglobin decreased
Insomnia (sleeplessness)
Leukopenia (less number of white blood cells in blood)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Intestinal perforation (complete penetration of the wall of the intestine)
Haemorrhage intracranial (bleeding within the skull)
Aggression
Anxiety
Insomnia (sleeplessness)
Intestinal obstruction
Mood altered (changes in mood)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

What are the common drug interactions of Depakote and Multaq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Headache (pain in head)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Intestinal perforation (complete penetration of the wall of the intestine)
Haemorrhage intracranial (bleeding within the skull)
Aggression
Anxiety
Insomnia (sleeplessness)
Intestinal obstruction
Mood altered (changes in mood)

What are the existing conditions these people have? *

Hyperkalemia (damage to or disease of the kidney): 3 people, 17.65%
Sleep Disorder: 2 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%
Pain: 1 person, 5.88%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.88%
High Blood Cholesterol: 1 person, 5.88%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.88%
Dementia (madness): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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