Depakote and Silvadene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote (divalproex sodium) and Silvadene (silver sulfadiazine). Common drug interactions include alcohol withdrawal syndrome among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote and Silvadene. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

On Jul, 09, 2026

30 people who take Depakote and Silvadene together, and have interactions are studied.

Depakote and Silvadene drug interactions.

What are the common drug interactions of Depakote and Silvadene, by gender? *:

female:

Alcohol withdrawal syndrome
Anger
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Blood phosphorus increased
Breakthrough pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Burns second degree
Cardiac failure congestive

male:

Depression
Affective disorder (mental disorder)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Urinary tract infection
Abdominal hernia
Acute psychosis (period of mentally unstable behaviour)
Adjustment disorder with anxiety
Ammonia increased

What are the common drug interactions of Depakote and Silvadene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute psychosis (period of mentally unstable behaviour)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Contusion (a type of hematoma of tissue in which capillaries)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic foot infection
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Excoriation (to tear or wear off the skin of)
Fall

40-49:

Affective disorder (mental disorder)
Chronic kidney disease
Depression
Drug ineffective
Feeling hot
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Head injury
Lacrimation increased
Peripheral coldness
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Asthenia (weakness)
Bedridden
Feeling hot
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Large intestine perforation (hole in large intestine)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colostomy
Hypoxia (low oxygen in tissues)
Pain in extremity

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 60.00%
Pain: 8 people, 26.67%
Agitation (state of anxiety or nervous excitement): 5 people, 16.67%
Nausea (feeling of having an urge to vomit): 3 people, 10.00%
Diabetes: 2 people, 6.67%
Anaemia (lack of blood): 2 people, 6.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 6.67%
Back Pain: 2 people, 6.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.67%
Chest Pain: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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